N-AcetylneuraminiC ACID (Sialic acid) o se aiga e iva-carbon acidic monosaccharides e tupu faʻalenatura i le iʻuga o filifili suka faʻapipiʻi luga o luga o sela ma soluble porotini. I le tino o le tagata, o le maualuga faʻatulagaina o sialic acid (pei o le N-acetylneuraminic acid) tupu i le faiʻai o loʻo auai ai o se vaega taua o le ganglioside fausaga i synaptogenesis ma neural faʻaliliuina.
igoa | N-AcetylneuraminiC ACID (SIALIC ACID) |
CAS | 131-48-6 |
Mama Atoatoa i Tulaga | 98% |
Igoa faʻapitoa | N-AcetylneuraminiC ACID |
Synonyms | Neuraminic acid |
Faiga Faʻavae Molecular | C11H19NO9 |
Taumaʻa Masele | 309.27 g / mol |
Melting Point | 185 ° C |
InChI Key | SQVRNKJHWKZAKO-UHFFFAOYSA-N |
faiga | paʻu |
Faʻaaliga | Paʻu paʻu paepae |
Afa o le Ola | / |
Solubility | / |
teuina o Meaai a Tuutuuga | Teu ile potu vevela, i totonu o se pusa uila ua tapunia, ia malu le ea i fafo, puipuia mai le vevela, malamalama ma le susu. |
talosaga | Aneti-soifua matua, supa o meaʻai |
Pepa o suʻega | iai |
O le Sialic acid o se vaitaimi masani mo se aiga e maua mai i le neuraminic acid, o le suka oona ma le iva-karaponi i tua. O le igoa foi lea mo le masani ai sui o lenei kulupu, N-acetylneuraminic acid (Neu5Ac po o le NANA).
N-AcetylneuraminiC ACID Sialic acid o loʻo maua lautele tufatufaina i meaola aano o manu ma i se laʻititi tulaga i isi meaola, e amata mai i fungus ma yeasts ma siama, tele lava i glycoproteins ma gangliosides (e tupu i le faaiuga o suka filifili fesoʻotaʻi i luga o sela ma polotini soluble). Talu ai ona e foliga mai na tuai ona aliaʻe mai i le evolusione. [Taʻua ai manaʻoga] Peitai, na maitauina i Drosophila embryos ma isi iniseti ma i le capsular polysaccharides o nisi ituaiga o siama. E masani a, e leʻo iai ni vailaʻau pe faʻaalia ni sialic acid.
I tagata o le faiʻai o loʻo maualuga le faʻasologa o le sialic acid, pe a fai o nei acid e taua tele i le neural transmission ma ganglioside fausaga i le synaptogenesis. Sili atu nai lo 50 ituaiga o sialic acid o loʻo iloaina, o nei mea uma e mafai ona maua mai i se mole o le neuraminic acid e ala i le suia o lana vaega amino o se tasi o ana vaega hydroxil. I se tulaga lautele, o le vaega amino o loʻo iai se acetyl poʻo se glycolyl kulupu, peitaʻi o isi suiga ua faʻamatalaina. O nei suiga faʻatasi ai ma fesoʻotaʻiga ua faʻaalia o ni ata maoti faʻatonutonu faʻatonutonu, o lea o nisi o latou e naʻo luga o nisi ituaiga o glycoconjugates i ni sela faapitoa. [3] O le hydroxyl sui e ono eseese tele; ua maua vaega acetyl, lactyl, methyl, sulfate, ma phosphate.
I mamamals, N-AcetylneuraminiC ACID (SIALIC ACID) e gaosia e le ate. O se taua meaʻai i susu susu, lea e mafai ona faʻalauteleina ai le atinaʻe o faiʻai ma neula sela i pepe ma tamaiti laiti, faʻaleleia le manatuaina ma le atamai, faʻaleleia atili le puipuiga o pepe ma tina;
N-AcetylneuraminiC ACID (SIALIC ACID) e le faʻaleagaina e enzymes i totonu o le digestive tract, e fausia ai glycoproteins e poloka ai le fesoʻotaʻiga o pathogens (siama, siama ma siama faʻamaʻi) i sela o le endocrine, ma mafai ona faʻaleleia le faʻailoaina o sela, faʻamamaina vailaʻau oona, puipuia faʻamaʻi o le pathological E. coli, faʻatonutonu le afa-ola o le toto polotini, ma o lea faʻaleleia atili ai le tagata puipuia galuega. I le taimi lava e tasi, N-AcetylneuraminiC ACID (SIALIC ACID) mafai ona faʻaleleia le manava faʻatamaia o vitamini ma minerals. Faʻaleleia le puipuiga o le pepe ma le tina; N-AcetylneuraminiC ACID (SIALIC ACID) lava ia fesoasoani i le aʻafiaga o le mautu fanau, fesoasoani i fafine maʻitaga ia fanauina ma le sologa lelei, ma faʻatelevaveina le toe faʻaleleia o tina.
O le pito i luga o sela o tagata o loʻo i ai le mafiafia vaega o le N-AcetylneuraminiC ACID (SIALIC ACID), faʻatonutonu sela ola ma sela faʻamatalaga fesoʻotaʻiga, N-AcetylneuraminiC ACID (SIALIC ACID) le lava e mafai ona taʻitaʻia ai i le toto sela sela ola ma le enzyme poromini laʻititi. Ma gutu N-AcetylneuraminiC ACID (SIALIC ACID) mafai ona faʻaleleia le totoʻo o le N-AcetylneuraminiC ACID (SIALIC ACID) i totonu o le tino, puipuia le sela luga N-AcetylneuraminiC ACID (SIALIC ACID) faʻamaligiina, tuai sela sela, ei ai le matafaioi o longevity .
Sialic acid-rich glycoproteins (sialoglycoproteins) fusia selectin i tagata ma isi meaola. Metastatic cancer cells e masani ona faʻaalia se maualuga tele o sialic acid-rich glycoproteins. Lenei overexpression o sialic acid luga luga fausiaina se le lelei totogi luga sela sela. Lenei faatupuina repulsion i le va o sela (sela teteʻe) ma fesoasoani nei tuai-laasaga kanesa sela ulufale atu i le toto tafe. Talu ai nei faʻataʻitaʻiga na faʻaalia ai le i ai o le sialic acid i totonu o le kanesa-faʻalilolilo extracellular matrix.
[1] Severi E.; Hood DW; Thomas GH (2007). "Sialic acid faʻaaogaina e siama pathogens". Microbiology. 153 (9): 2817–2822. faia: 10.1099 / mic.0.2007 / 009480-0. PMID 17768226
[2] Schauer R. (2000). "Ausia ma luʻitau o le sialic acid suʻesuʻega". Glycoconj. J. 17 (7–9): 485–499. faia: 10.1023 / A: 1011062223612. PMC 7087979. PMID 11421344
[3] Racaniello, Vincent (5 Me 2009). "Faʻamaʻi pipisi siama Influenza i sela: matafaioi o eseese sialic acid". Virology Blog Toe aumai ile 10 Aperila 2019.
[4] Warren, Leonard; Felsenfeld, Herbert (1962). "O le Biosyntesis o Sialic Acids" (PDF). Le Tusi o Talaaga o mea tau vailaʻau. 237 (5): 1421.