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Nicotinamide adenine dinucleotide (NAD) paʻu (53-84-9)

Nicotinamide adenine dinucleotide (NAD) o le pulu o se cofactor e totonugalemu i le metabolism. O loʻo maua i sela ola uma, o le NAD paula e taʻua o le dinucleotide aua e aofia ai nukototida e lua faʻatasia e ala i a latou vaega kulatisi. E tasi le nucleotide o loʻo aofia ai se adenine nucleobase ma le isi nicotinamide. O le NAD paula e lua ituaiga: o le faʻaogaina ma faʻaititia pepa, o faʻapuʻupuʻu o NAD + ma NADH faʻatulagaina.

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Nicotinamide adenine dinucleotide paʻu vitio

 

 

NAD pulu (53-84-9) Faʻavae Faʻamatalaga

igoa Nicotinamide adenine dinucleotide (NAD) pauu
CAS 53-84-9
Mama Atoatoa i Tulaga 99%
Igoa faʻapitoa beta-Diphosphopyridine nucleotide
Synonyms Beta-NAD

NAD

NAD+

Faiga Faʻavae Molecular C21H27N7O14P2
Taumaʻa Masele 663.4 g / mol
Melting Point 160 ° C (320 ° F; 433 K)
InChI Key BAWFJGJZGIEFAR-NNYOXOHSSA-N
faiga malō
Faʻaaliga Paʻu paʻu
Afa o le Ola /
Solubility Suavai Suavai 2.14 mg / mL
teuina o Meaai a Tuutuuga I totonu o se pusa uila ua tapunia, ia puipuia le ea i fafo, puipuia mai le vevela, malamalama ma le susu.
talosaga mafai ona fesoasoani e toe faʻafoi faʻailoga o le matua ma faʻaititia ai le lamatiaga o le tele faʻamaʻi
Pepa o suʻega iai

 

NAD pulu (53-84-9) Aoao Faamatalaga

NAD efuefu, puʻupuʻu mo le nikotinamide adenine dinucleotide. O le coenzyme e tupu i le tele o sela ola ma gaioiga o se electron taliaina. NAD efuefu o loʻo faʻaaogaina faʻasolosolo ma NADH o se oxidizing pe faʻaititia le sooupu i metabolic tali.

 

Nicotinamide adenine dinucleotide Talafaʻasolopito

O le coenzyme NAD + na muaʻi mauaina e le tusitala o meaola a Peretania o Arthur Harden ma William John Young i le 1906. Na latou taʻua le mafuaʻaga le mautinoa mo lenei aafiaga o se coferment. E ala ile umi ma le faigata ole faʻamamaina mai le feʻaveaʻiga, o lenei vevela-mautu vaega na faʻailoa mai o le nucleotide suka phosphate e Hans von Euler-Chelpin. I le 1936, o le saienitisi Siamani Otto Heinrich Warburg na faʻaalia le gaioiga o le nucleotide coenzyme i le hydride transfer ma faʻailoa mai le vaega o le nicotinamide o le nofoaga o redox tali.

Vitamin muamua o NAD + na muamua faʻailoaina i le 1938, ina ua faʻaalia e Conrad Elvehjem o le ate ei ai le "anti-uliuli laulaufaiva" gaioiga i le tulaga o le nicotinamide. I le 1939, na ia saunia ai le faʻamaoniga malosi muamua o le niacin o loʻo faʻaaogaina e synthesize le NAD +. I le amataga o le 1940, o Arthur Kornberg na muamua mauaina se enzyme i le biosynthetic pathway. I le 1949, le American biochemists Morris Friedkin ma Albert L. Na faʻamaonia e Lehninger o le NADH faʻafesoʻotaʻi metabolic pathway pei o le citric acid cycle ma le synthesia o le ATP i le oxidative phosphorylation. I le 1958, na maua ai e Jack Preiss ma Philip Handler le ogatotonu ma le fualaʻau o loʻo aʻafia i le biosynthesis o le NAD +; salvage synthesis mai le nicotinic acid ua taʻua o le Preiss-Handler ala. I le 2004, Charles Brenner ma tagata faigaluega na latou tatalaina le auala o le nikotinamide riboside kinase i le NAD +

 

Efuefu NAD (53-84-9) Masini o Faatinoga

Nicotinamide adenine dinucleotide (NAD) o paʻu o loʻo aʻafia i redox reaksi, o loʻo aumaia ni eletise mai le tasi tali atu i le isi. O le cofactor e, o lea, e maua i ni ituaiga se lua i totonu o sela: NAD + o se faʻaavanoaina sui - e taliaina elektron mai isi mole ma ua faʻaititia. O lenei aʻafiaga e fausia ai le NADH, ma e mafai ona faʻaoga e avea ma sui faʻaitiitia e foai atu i ai eletise. O nei gaioiga e faʻaliliuina atu le eletise o le galuega autu a le NAD. Peitai, e faʻaaogaina foi i isi sela faʻagasologa, aemaise lava se vaega o le enzymes e faʻaopopoina pe faʻamamaina vailaʻau mai vaega polotini, i le faʻasologa o suiga. Ona o le taua o nei gaioiga, o enzymes aofia ai i le NAD metabolism o sini mo sailiiliga vailaau.

 

Nicotinamide adenine dinucleotide Talosaga

Nicotinamide adenine dinucleotide (NAD) o le pauta e avea ma fafie mo le tele o meaola autu, pei o le:

1) Faʻaliliuina o meaʻai i le malosi

2) Toe faʻaleleia le DNA ua faʻaleagaina

3) Faʻamalosia puipuiga o sela 'puipuiga

4) Faʻatulaga o lou tino i totonu le uati poʻo le circadian rhythm

 

NAD paula (53-84-9) Tele suʻesuʻega

Talu ai o le tele o suʻesuʻega i le paʻu o le Nicotinamide adenine dinucleotide (NAD) paʻu e sau mai suesuega i manu, e le mafai ona faia ni faʻaiuga manino e uiga i lona aoga mo tagata. Nei o ono ono aoga mo le soifua maloloina o le Nicotinamide adenine dinucleotide (NAD) paʻu:

  1. Faatoagaina mai Enzymes e ono faʻamalosia le soifua maloloina soifua maloloina
  1. Ia Fesoasoani Puipui Sela Brain

Ole NAD + e tele lona sao e fesoasoani ile faiʻai o lou faiai ma tausaga.

I totonu o sela faiʻai, NAD + fesoasoani e faʻatonutonu le gaosiaina o le PGC-1-alpha, o se polotini e foliga mai e fesoasoani e puipuia sela mai le faʻamama o le oxidative ma faʻaletonu ai le mitochondrial function. E talitonu le au suʻesuʻe, o le mafatiaga ole oxidative male faaletonu ole mitochondrial function e fesoʻotaʻi ma faaletonu ole faiʻai pei ole matutua e pei ole Alzheimer's and Parkinson's disease.

  1. Mafai e Faʻaititia le Maʻi Lamatia Maʻi

O le matua o se mafuaʻaga tele lamatiaga mo fatu faamaʻi, o le mafuaaga autu o le oti o le lalolagi. E mafai ona mafua ai le toto faʻapipiʻi pei o lou aorta avea mafiafia, strait ma itiiti fetuʻutuʻunaʻi. O ia suiga e mafai ona siitia ai le maualuga o le toto maualuga ma faʻamalosi ai lou fatu.

I meaola, faʻafouina le NAD + fesoasoani toe faʻaleleia tausaga e faatatau i suiga o alatoto

  1. Mafai ona faʻaititia le kanesa lamatia

Ole maualuga ole NAD + e fesoasoani e puipuia mai faʻafitauli ole DNA ma le faʻamama ole faʻaititia, e fesoʻotaʻi ma le kanesa

  1. Faʻateleina maloloina le soifua maloloina o maso

O le siʻitia o le NAD + na fesoasoani e faʻaleleia atili ai le maso, malosi ma le tumau i moa matutua

 

Nicotinamide adenine dinucleotide Faʻamatalaga

  • [1] Sakuraba H, Kawakami R, Ohshima T (2005). "First Archaeal Inorganic Polyphosphate / ATP-Dependent NAD Kinase, mai le Hyperthermophilic Archaeon Pyrococcus horikoshii: Cloning, Expression, ma Characterization". Appl. Siosiomaga Microbiol. 71 (8): 4352–8. faia: 10.1128 / AEM.71.8.4352-4358.2005. PMC 1183369. PMID 16085824.
  • [2] Katoh A, Uenohara K, Akita M, Hashimoto T (2006). "Early Steps in the Biosynthesis of NAD i Arabidopsis Amata ma Aspartate ma Tupu i le Plastid". Laʻau Physiol 141 (3): 851–7. faia: 10.1104 / pp.106.081091. PMC 1489895. PMID 16698895.
  • [3] Chen YG, Kowtoniuk WE, Agarwal I, Shen Y, Liu DR (Tesema 2009). "LC / MS auiliiliga o cellular RNA faʻaalia NAD-fesoʻotaʻi RNA". Nat Chem Biol. 5 (12): 879–881. faia: 10.1038 / nchembio.235. PMC 2842606. PMID 19820715.
  • [4] Gomes AP, Tau NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA (19 Tesema 2013). "Faʻaleaogaina NAD + Faʻaosofia se Pseudohypoxic State Faʻalavelaveina Nuclear-Mitochondrial Fesoʻotaʻiga i le taimi o le Matua". Sela 155 (7): 1624–1638. fai: 10.1016 / j.cell.2013.11.037. PMC 4076149. PMID 24360282.
  • Mea uma E te Manaomia E Iloa e uiga ia Nicotinamide Riboside Chloride

 

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