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Masini CAD-031 (2071209-49-7)

CAD-031 le paʻu (CAD031) o se mea fou faiʻai le faiʻai, J147-faʻasologa na faʻalauteleina le faʻamalositino gaioiga i luga o le J147 i tagata neural Preursor Cells (NPCs); faʻaosofia foi le vaevaeina o NPC i lalo o le subventricular sone o le tuai APPswe / PS1E9 isumu; laveai matua cortical neurons mai oxytosis, ma faʻaititia faʻaititia faʻamama toto ma EC50 o 20 nM; puipuia foi le leiloa o le malosi metabolism e tau atu i neura sela maliu i se in vitro ischemia faataitaiga ma EC50 o 47 nM; faʻatinoina le gaʻo gaʻo gaʻo ma fula, faʻaalia togafitiga lelei i luga o le mafaufau ma faʻatupuina faʻataʻamilomilo i tikeri faʻataʻitaʻiga o TA.

Gaosiga: Faʻaputuga Gaosiga
afī: 1KG / ato, 25KG / talipalau
Wisepowder ei ai le gafatia e gaosia ma tuʻuina atu se aofaʻi tele. Gaosia uma i lalo o le cGMP tulaga ma faiga pulea lelei atoatoa, pepa uma suʻega ma faʻataʻitaʻiga avanoa.
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CAD-031 pauu (2071209-49-7) vitio

 

CAD-031 pauu (2071209-49-7) Faʻamatalaga Faʻavae

igoa CAD-031 le paʻu
CAS 2071209-49-7
Mama Atoatoa i Tulaga 98%
Igoa faʻapitoa Acetic acid, 2,2,2-trifluoro-, (2E) -1- (2,4-dimethylphenyl) -2 - [[3- (trifluoromethoxy) phenyl] methylene] hydrazide
Synonyms CAD 31); CAD-031 (CAD031
Faiga Faʻavae Molecular C18H14F6N2O2
Taumaʻa Masele 404.312
Melting Point Leai se Faʻamaumauga
InChI Key Leai se Faʻamaumauga
faiga Leai se Faʻamaumauga
Faʻaaliga Leai se Faʻamaumauga
Afa o le Ola Leai se Faʻamaumauga
Solubility Leai se Faʻamaumauga
teuina o Meaai a Tuutuuga -20 ° C 12 Masina; 4 ° C 6 Masina
talosaga Leai se Faʻamaumauga
Pepa o suʻega iai

 

CAD-031 pauu (2071209-49-7) Aoao Faamatalaga

O le pauta o le CAD-031 na alofagia i le faʻatonutonuina o le puipuia o nisi o mea oona na tutupu i faʻafitauli tuai o le neurodegenerative. O le pauta o le CAD-031 o loʻo i ai ni mea taua i totonu o le neula e ono o loʻo faʻataʻitaʻia ai le oona i le faiʻai tuai. O vailaʻau ma vailaʻau faʻasaienisi o loʻo faʻailoa mai ai o le CAD-031 o le faiʻai e tuʻi i totonu ma e ono sefe. A fafagaina i matutua, faʻailoga mole APPswe / PS1ΔE9 AD amata ile 10 masina le matua mo le 3 masina faʻaopoopo i se togafitiga faʻasolosolo o le faʻamaʻi, na i ai le faʻaititia o le manatuaina faʻaletonu ma faiʻai pupuga, faʻapea foʻi ma le faʻateleina o le faʻaaliga o synaptic proteins. Laʻititi-molemole metabolic faʻamaumauga mai le faiʻai ma le plasma faʻaalia o le tele o aʻafiaga o le CAD-031 e faʻatotonugalemuina i gaʻo gaʻo gaʻo ma pupuga. O le suʻesuʻega o faʻamaumauga o faʻamatalaga o gafa na faʻaalia ai o le CAD-031 na i ai ni ona aafiaga tetele i le fausiaina o le synaps ma ala malosiʻaga metabolic AD.

 

CAD-031 (2071209-49-7) Talosaga

  1. CAD-031 o le lautele lautele neuroprotective
  2. CAD-031 o loʻo i ai se sili faʻamanuiaina o vailaʻau ma saogalemu
  3. CAD-031 suia nisi o itu o le atoatoa le mafaufau i isumu tuai transgenic AD
  4. RNA-seq auiliiliga fautua mai o le CAD-031 e faʻafetaui le fulafula, synaptic soifua maloloina, ma metabolism
  5. FA-031 faaitiitia pupuga ma faʻateleina markers mo neurogenesis ma synapses
  6. TA-31 taulia lipid metabolism

 

CAD-031 (2071209-49-7) Faʻamatalaga

  1. Daugherty D, 'ua al. Alzheimers Ua iai. 2017 Iulai 14; 9 (1): 50.
  2. Chen Q, Prior M, Dargusch R, Roberts A, Riek R, Eichmann C, et al. O se tala fou o le neurotrophic vailaau mo le faʻalauteleina o le mafaufau ma le faʻamaʻi Alzheimer. PLOS Tasi. 2011; 6 (12): e27865. doi: 10.1371 / tusi.pone.0027865 [PMC free article] [PubMed] [CrossRef] [Google sikola]
  3. Prior M, Dargusch R, Ehren JL, Chiruta C, Schubert D. O le neurotrophic compound J147 ua suia faaletonu le mafaufau i isumu faamai o le Alzheimer ua matutua. Alzheimers Res Ther. 2013; 5 (3): 25. faia: 10.1186 / alzrt179. [PMC leai se tala] [PubMed] [CrossRef] [Google Scholar]
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  5. Muamua M, Goldberg J, Chiruta C, Farrokhi C, Kopynets M, Roberts AJ, et al. Filifilia mo le neurogenic gafatia e avea ma isi mea mo Alzheimer faamai vailaau maua. Mataʻitusi ole Alzheimers. 2016; 12 (6): 678– doi: 10.1016 / j.jalz.2016.03.016. [PMC free article] [PubMed] [CrossRef] [Google sikola]
  6. Currais A, Goldberg J, Farrokhi C, Chang M, Prior M, Dargusch R, et al. A tuufaatasia multiomics auala agai i le malamalama i le sootaga i le va o matua ma le moe. Matutua. 2015; 7 (11): 937– doi: 10.18632 / matutua.100838. [PMC free article] [PubMed] [CrossRef] [Google sikola]

 

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