Products

Palmitoylethanolamide (PEA) efuefu (544-31-0)

Palmitoylethanolamide (PEA) o le pulu o se endogenous fat acid acid amide. O se tagata vaivai o le cannabinoid 1 (CB1) ma le cannabinoid 2 (CB2) e taliaina. Palmitoylethanolamide e galue e ala i le fusifusia i se mea e le masani ai cannabinoid receptor e tutusa ma CB2, e faʻaalia ai aneti-inflamasi, anti-nociceptive, neuroprotective, ma anticonvulsant meatotino i vivo. Faʻatinoina malosi aneti-inflamasi gaioiga e ala i le faʻaogaina o le PPARα, galue o se mea filifilia agonist mo GPR55 talini (EC50 = 4, 19 800 ma> 30 000 nM i le GPR55, CB2 ma CB1 talipupuni).

Gaosiga: Faʻaputuga Gaosiga
afī: 1KG / ato, 25KG / talipalau
Wisepowder ei ai le gafatia e gaosia ma tuʻuina atu se aofaʻi tele. Gaosia uma i lalo o le cGMP tulaga ma faiga pulea lelei atoatoa, pepa uma suʻega ma faʻataʻitaʻiga avanoa.
Category:

Pamaitoylethanolamide (PEA) efuefu vitio

 

Palmitoylethanolamide (PEA) paʻu (544-31-0) Faʻavae Faʻamatalaga

igoa Palmitoylethanolamide (PEA) efuefu
CAS 544-31-0
Mama Atoatoa i Tulaga solubility suauʻu, vai solubility, lelei efuefu, lautele pauta
Igoa faʻapitoa Palmitoylethanolamide

N- (2-Hydroxyethyl) hexadecanamide

Synonyms Palmidrol; Impulsin; 544-31-0; N-palmitoylethanolamine; Palmitinsaeure-beta-hydroxyethylamid; (Hydroxyethyl) palmitamide; 2- (Palmitoylamino) ethanol; 2-Palmitamidoethanol; AM 3112; Loramine P 256; Mackpeart DR 14V; N- (2-Hydroxyethyl) palmitamide; N-Hexadecanoylethanolamine; NSC 23320; Palmitic Acid Monoethanolamide; Palmitic Monoethanolamide
Faiga Faʻavae Molecular C18H37NO2
Taumaʻa Masele 299.49
Melting Point 97-98 ° C
InChI Key HXYVTAGFYLMHSO-UHFFFAOYSA-N
faiga O se maa malosi
Faʻaaliga Paʻepaʻe e Paʻu Paʻepaʻe paʻu
Afa o le Ola 0.292 Aso (12-itula aso; 1.5E6 OH / cm3)
Solubility Soluble i le DMSO (20 mM), ethanol (25 mM), chloroform, THF (i le 30 ° C), ma le DMF (~ 10 mg / ml).
teuina o Meaai a Tuutuuga Faleoloa i se malu ma mago nofoaga, alu ese mai tuusaʻo la
talosaga Palmitoylethanolamide o le endogenous CB2 cannabinoid receptor agonist ma filifili GPR55 agonist
Pepa o suʻega iai

 

Palmitoylethanolamide (PEA) pauta (544-31-0) paʻu lautele Faʻamatalaga

Palmitoylethanolamide efuefu o le endogenous cannabinoid maua i faiʻai, ate, ma isi mamalia sela. O se ligand vaivai o le cannabinoid 1 (CB1) ma le cannabinoid 2 (CB2) mauaina, ua maua e taofia le gaʻo acid amide hydrolase (FAAH) ((IC50 = 5.1 μM) Modulate mast cell activation. Palmitoylethanolamide efuefu faʻaalia anti - o le N- (long-chain-acyl) ethanolamine, o le endocannabinoid ma le N- (saturated fatty acyl) ethanolamine. E maua mai i le hexadecanoic acid. Palmitoylethanolamide paʻu. gaioiga e ala i le fusifusia i se le faʻailoaina cannabinoid talimalo e tutusa ma CB2.E faʻapea foi ona galue o se filifilia tagata faʻamalosia o le GPR55 mauaina.

Palmitoylethanolamide palu, (e faʻaigoaina palmitoylethanolamine poʻo le N-2 hydroxyethyl palmitamide), o se tasi o sili ona taua o le endukous painkilling ma anti-inflammatory complex and ua faamaonia i lona aoga mo le ogaoga ma le tiga tiga. Ona o le vailaau e avea o se vailaau tiga masani, o se sili lelei auala mo masani vailaau e ono mafua ai itu afaina.

Palmitoylethanolamide palu ua faʻaaoga mai mo le tele o tausaga i Netherlands ma Europa, ae talu mai le 1990 o le fiafia i le US ua siʻitia. O faʻavasegaina o se "taumafa mo faʻafomai togafitiga" i Europa ma o se faʻaopoopoga meaʻai i le US

 

Palmitoylethanolamide (PEA) pauu Talafaasolopito

Palmitoylethanolamide (PEA) paʻu, o le masani ai o le amide o le ethanolamine ma le palmitic acid, o se endogenous lipid e suia ai le tiga ma le fulafula. O le fiafia i le anti-inflammatory meatotino o le palmitoylethanolamide paʻu na muamua maitauina i le amataga o le 1950 e Coburn et al. (1954) o le na mauaina o le fafagaina o puaa guinea o le taumafataga maualuga i fuamoa yolk puipuia i latou mai faʻataʻitaʻiga allergy. Suʻesuʻega mulimuli ane vavaeʻese ma faʻamamaina palmitoylethanolamide paʻu mai fuamoa yolk ma faʻailoa mai le anti-inflammatory meatotino i manu. O le fiafia ile suʻesuʻe ile NAE na toe fafagu mai ile 1990's ina ua maeʻa le mauaina o le isi endogenous NAE, AEA, ma isi meatotino ile vaega galue ole vailaʻau. O le faʻataʻitaʻiga o vailaʻau o le cannabinoid (filifilia CBi ma CB2) ma le gafa o le filifilia o le CB receptor ligands na maua ai mea faigaluega e faʻatelevave ai suʻesuʻega gaioiga. Talu mai lena taimi o le tele o faʻamatalaga molimau na aoina mai manu ma tagata suʻesuʻega ua faʻaalia ai o le palmitoylethanolamide paʻu o loʻo i ai le anti-inflammatory ma analgesic meatotino pe a tuʻuina atu i auala eseese o pulega.

 

Palmitoylethanolamide (PEA) Mechanism O Faatino

Palmitoylethanolamide efuefu faʻagaoioia le malosi-faʻamalosia, gaʻo-susunuina, ma aneti-afaina PPAR alpha. I le faʻagaoioia o lenei ki polotini, Palmitoylethanolamide efuefu taofi le gaioiga o pro-afaina genes ma le gaosiaina o le tele o vailaʻau oona.

Palmitoylethanolamide paʻu faʻaititia le gaioiga o le pamu genes FAAH e talepeina masani cannabinoid anandamide. Ole mea lea e faʻateleina ai le faʻafilemu o le anandamide i lou tino, e fesoasoani ai i le faʻafitauli o le tiga ma faʻateleina le toʻafilemu. E ono faʻatinoina foʻi le cannabinoid receptors (CB2 ma CB1).

Palmitoylethanolamide pauu o loʻo aofia ai le palmitic acid ile fausaga. Ole amataga ole gaʻo ole Palmitoylethanolamide ole tino ole mea moni ole gaʻo ole gaʻo lea.

Ae ui i lea, o le faʻateleina o le aʻafia o le palmitic acid poʻo isi gaʻo gaʻo e le afaina ai le gaʻoa o le Palmitoylethanolamide i le tino. E mafua ona o lou tino na faʻaaogaina le Palmitoylethanolamide pauu pe a manaʻomia e faʻafetauiina le pupuga poʻo le tiga, ma o lona maualuga e masani foi ona eseese i le aso atoa. Ole auala pito sili e maua ai penefiti ole Palmitoylethanolamide pauu e masani ona faʻaopopo iai, poʻo isi mea e aoga tele ile Palmitoylethanolamide.

 

Palmitoylethanolamide (PEA) Talosaga

Palmitoylethanolamide (PEA) O le pulu o le endogenous fat acid acid, o se tala faatatau o le endocannabinoid anandamide (AEA), o le aiga o N-acylethanolamines (NAE). Ua faʻasaʻoloto le NAE mai sela e tali atu ai ile faʻaosofia ole leaga. E pei o mea uma NAE, o le Palmitoylethanolamide (PEA) efuefu ei ai se aʻafiaga i le lotoifale, ma lona aano e faʻatulagaina latalata i le paleni o le gaosiga ma faʻaleagaina gaioiga. Lua intracellular amidases, faʻaalia i sela afaina, ua aʻafia i le lipid amide degradation: gaʻo-acid amide hydrolase (FAAH) ma N-acylethanolamine hydrolyzing acid amidase (NAAA). Palmitoylethanolamide (PEA) Malosiaga faʻamaonia ua faʻaalia e fusifusia i se mea e puipuia ai le sela-nucleus (o le faaniukilia laupepa) ma faʻaaoga se tele o mea ola faʻagaioioiga e fesoʻotaʻi ma tiga tiga ma le pupuga.

 

Palmitoylethanolamide (PEA) Tele sailiiliga

O le Palmitoylethanolamide (PEA) Powder o se mea masani e gaosia e le tino ma e maua i taumafa eseese. E le o se opioid. E le faʻatama. Muamua suʻesuʻega faʻailoa mai o le Palmitoylethanolamide (PEA) Powder e le atiaʻe le faʻapalepaleina o vailaʻau pe lemu foʻi ona mou atu le aoga i le taimi e pei ona tupu i opioids. Ua faʻaalia e sefe mo tagata mamaʻi e aunoa ma le lipotia o aʻafiaga matuia ma ua manatu e leai se oʻona pe oona faʻaona. E le faʻalavelave i isi togafitiga faʻafomaʻi, pe faʻamalosia ai fegalegaleaiga o fualaʻau-faʻasaina. E leai ni faʻailoaina lauiloa mo Palmitoylethanolamide (PEA) Powder, ma tagata mamaʻi e faʻaititia le fatugaʻo ma le ate e mafai ona togafitia i le Palmitoylethanolamide (PEA) Powder, ona o lona metabolism e faʻatulagaina ma sela ma tutoʻatasi mai fatugaʻo ma ate gaioiga. E pei foi o le tele o vailaʻau, o le saogalemu ma le umi faʻaaoga i luga o le 60 aso e leʻi lelei suʻesuʻeina e ui lava o lipoti o loʻo lipotia mai i tusitusiga o taimi umi faʻaaogaina e aunoa ma faʻafitauli faʻailoa.

 

Palmitoylethanolamide (PEA) Faʻamatalaga

  • [1] Cruccu G, Di Stefano G, Marchettini P, Truini A.CNS Neurol Disord Drug Sini. 2019 Iulai 3. doi: 10.2174 / 1871527318666190703110036. PMID: 31269891
  • [2] Noli C, Della Valle MF, Miolo A, Medori C, Schievano C; Skinalia Clinical Research Group.Vet Dermatol. 2019 Jun 24. doi: 10.1111 / vde.12764. FAAMATALAINA: 31237065
  • [3] Contarini G, Franceschini D, Facci L, Barbierato M, Giusti P, Zusso MJ Neuroinflammation. 2019 Jun 20; 16 (1): 126. doi: 10.1186 / s12974-019-1514-4. PMID: 31221190
  • [4] Boccella S, Marabese I, Iannotta M, Belardo C, Neugebauer V, Mazzitelli M, Pieretti G, Maione S, Palazzo E. Int J Mol Sci. 2019 Aperila 9; 20 (7). pii: E1757. doi: 10.3390 / ijms20071757. PMID: O le 30970677
  • E i ai ni penefiti pa'ū o Palmitoylethanolamide (PEA)?

 

Tusitusiga masani