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L - (+) - Ergothioneine (EGT) efuefu (497-30-3)

L - (+) - Ergothioneine (EGT) o se natura faʻamalosiʻauʻau amino-acid antioxidant biosynthesized i nisi siama ma fungi. O se taua bioactive mea na faʻaaogaina e avea o se radial scavenger, o le ultraviolet ray faamama, o se faʻatonutonuina o le faʻaitiitia-faʻaititia o tali ma le bioenergetics feaveaʻi, ma se physiolog cytoprotector, etc.

Gaosiga: Faʻaputuga Gaosiga
afī: 1KG / ato, 25KG / talipalau
Wisepowder ei ai le gafatia e gaosia ma tuʻuina atu se aofaʻi tele. Gaosia uma i lalo o le cGMP tulaga ma faiga pulea lelei atoatoa, pepa uma suʻega ma faʻataʻitaʻiga avanoa.
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L - (+) - Ergothioneine (EGT) (497-30-3) vitio

 

 

L - (+) - Ergothioneine Base Faʻamatalaga

igoa L - (+) - Ergothioneine (EGT)
CAS 497-30-3
Mama Atoatoa i Tulaga 98%
Igoa faʻapitoa (α-S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium totonu masima
Synonyms Ergothionine; L - (+) - Ergothioneine; Erythrothioneine
Faiga Faʻavae Molecular C9H15N3O2S
Taumaʻa Masele 229.30
Melting Point 255-259 ° C
InChI Key SSISHJJTAXXQAX-ZETCQYMHSA-N
faiga malō
Faʻaaliga papaʻe malo
Afa o le Ola lata ane 30 aso
Solubility Soluble i le vai (50 mg / ml), acetone, vevela ethanol, ma metanol.
teuina o Meaai a Tuutuuga -20 ° C (des.)
talosaga O le antioxidant ma le free radical scavenger
Pepa o suʻega iai

L - (+) - Ergothioneine (EGT) Faamatalaga Aoao

L-Ergothioneine o se mautu lelei faʻaola e mafai ona maua i lalo o tulaga o le tele o faʻamalologa faʻamalosi i laʻau ma aano o manu. E mafai e L-ergothioneine ona faʻatamaia le leai o ni mea e puipuia ai ma puipuia ai sela mai le UV-faʻatupuina le ROS ma le sili atu ona lelei nai lo le antioxidants coenzyme Q (10) poʻo le idebenone, ma avea ai o se sili atu ona aoga antioxidant. Ua faʻaalia le i totonu o le vailaʻau o se mea e le oona ai le vailaʻau, e faʻaosofia ai le olaola faʻaosofia e le hydrogen peroxide (H2O2), ma taofia le faʻatupuina ole DNA e le peroxynitrite (ONOO-) i le laina o tagata (N-18-RE- 105).

L - (+) - Ergothioneine (EGT) efuefu (497-30-3)

 

L - (+) - Ergothioneine (EGT) (497-30-3) Talaʻaga

EGT e faia i ni nai meaola, faʻapitoa Actinobacteria, Cyanobacteria, ma nisi fungus. Ergothioneine na maua i le 1909 ma faʻaigoa i le ergot fungus na muamua faʻamamaina ai, ma lona fausaga na fuafuaina i le 1911.

 

L - (+) - Ergothioneine (EGT) Tisaini Faʻatinoga O gaioiga

l - (+) Ergothioneine o se masani tupu thiol amino acid ma meatotino antioxidant ma ono ono aoga o se faʻalautelega meaai. E ui lava i lona seneturi-tuai faʻailoaina ma lautele lautele tufatufaina i tagata soifua maloloina, laitiiti iloa o lana auala o gaioiga ma le saogalemu.

 

L - (+) - Ergothioneine (EGT) paʻu Talosaga

L - (+) - O le Ergothioneine ua faʻaaogaina:

  • o se vaega o le matua matutua auala mo cumulus-oocyte complexes (COCs) e faʻataʻitaʻi le puipuiga puipuiga i luga o le lipid peroxide formation
  • avea o se vailaʻau oona e faʻataʻitaʻi ai ituaiga maʻi suka 2

L-Ergothioneine – o se ituaiga fou o natura antioxidant

EGT o se masani chiral amino-acid antioxidant biosynthesized i nisi siama ma fungi. O se taua bioactive mea ua faʻaaogaina e avea o se radial scavenger, o le ultraviolet ray faamama, o se faʻatonutonuina o le faʻaitiitia-faʻaititia o tali ma le bioenergetics feaveaʻi, ma se physiolog cytoprotector, etc.

L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), e faʻaigoa foi o (S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- 4-ethanaminium masima totonu, na muaʻi aumai i le ergot e Tanret C i le 1909, ona maua ai foi lea i toto o manu. Pure EGT o le paʻepaʻe paʻepaʻe, e maitauina ile vai, (faʻasaʻoina 0.9mol / L ile potu vevela). Autoxidation e le mafai ona tupu i tulaga ole pH paʻu poʻo le fofo malosi. EGT mafai ona i ai i le lua isomer foliga - se thiol foliga ma se thione pepa, pei ona faʻaalia i lalo:

Faatasi ai ma tulaga lelei o le tele-galuega, EGT e tu i fafo atu o le tele o isi antioxidants. Tulaga lelei (faʻatusatusa i le glutathione, cysteine ​​ma isi):

E sili atu ona faigofie le faʻaputu i le sela ma e sili atu le mautu o loʻo faʻaalu ile malosi nai lo isi vailaʻau.

——EGT e sili atu le aoga i le faaitiitia sela maliu e mafua mai pyrogallol.

- E masani ona siʻitia le ROS e puipuia ai le faʻamalologa, aʻo le glutathione ma isi e latou te auʻeseina le leai o se mea e tupu fua, o isi vailaʻau faʻataʻapeʻapeina le faʻaolaina o le faʻaogaina.

  • faʻapea o se tulaga lelei i le solute feaveai porotini 22 A4 (SLC22A4) felauaiga assay

L - (+) - Ergothioneine e talafeagai mo le faʻaaogaina i le suʻesuʻega o lona gaioiga ma 2,2'- ma 4,4'-dipyridyl disulphide (2-Py-SS-2-Py ma 4-Py-SS-4- Py), mo le faʻatupuina o sela faʻataʻitaʻia aʻo faia le vitro kinase gaioiga faʻataʻitaʻi mo ATM (Ataxia telangiectasia mutated) poʻo ATR (ATM- ma RAD3-fesoʻotaʻi).

 

L - (+) - Ergothioneine (EGT) Tele suʻesuʻega

L - (+) - Ergothioneine (EGT) efuefu (497-30-3)

FAʻASOAGA O FAʻAFETAI

Iʻuga: EGT o le sili ona gaioi lava faʻavave o le saoloto rads faʻatusa faʻatusa i masani klasik antioxidants pei GSH, uric acid ma trolox. Aemaise lava, o le maualuga maualuga faʻapitoa tulaga na faʻaalia e EGT vs. peroxyl radicals e maua ai le 25% maualuga atu nai lo le tau na mauaina ma le faʻasino antioxidant trolox. O le faʻatulagaina o le EGT e faʻatatau i le hydroxyl rads, e 60% maualuga atu, pe a faʻatusatusa i le uric acid, lea e fai ma sui o le antioxidant vs. hydroxyl rads. Ile faʻaiuga ole EGT na faʻaalia ai foi le maualuga o le antioxidant gaioiga e agaʻi atu i le peroxynitrite, e iai lona malosi e 10% maualuga atu nai lo le uric acid.

O ISI FUAFUAGA

EGT foi aʻafiaga i le faʻatonutonuina intracellular malosiaga,

faaleleia le puipuiga malu,

faaleleia le saoasaoa tulaga o sperm,

puipuia le ate mai manuʻa,

taofia le pupuga,

neurodegeneration,

atinae faaletonu ma cataract.

5-10mg i le iunite mo le tagata matua ma 2-3 iunite taumafataga faifai pea e taua i lau taumafataga i aso uma.

Punavai: Li Yiqun, Zhou Nianbo. Biology Functions and Applications o le EGT [J]. Food Engineering , 2010,9 (3) : 26-28.

■ O mea e aʻafia o loʻo lisiina i lalo:

  • Tamaiti (3-11 tausaga)
  • 0l XNUMX mg / aso
  • Autalavou (11-21 tausaga)
  • ≤30 mg / aso
  • Matutua (21-80 tausaga)
  • ≤30 mg / aso

Manatua:

  • Fua i fanau ma tagata matutua (3 -80 tausaga le matutua)
  • E le fautuaina le faʻaaogaina mo fafine maʻitaga poʻo faʻamalositino.

Faʻamatalaga puna: Tetrahedron pe a apalai mo US NDI

■ Fautuaina faʻamaumauga: 10.5mg / g mo OXIS's ADI (Talia le taliaina i aso uma).

 

L - (+) - Ergothioneine (EGT) powde Tusitusiga

  • Tanret Sur une base nouvelle retiree du seigle ergote, lʻergothioneine Compt. Faʻavae., 149 (1909), itulau 222-224
  • Akanmu D, Cecchini R, Aruoma OI, Halliwell B (Iulai 1991). "O le antioxidant gaioiga a le ergothioneine". Arch Biochem Biophys. 288 (1): 10–
  • "Ergothioneine". PubChem, National Center mo Biotechnology Faʻamatalaga, US National Library of Medicine. 2 Novema 2019. Toe aumai 7 Novema 2019.
  • L-Ergothioneine (EGT): O Se Diet ‐ Mauaina Antioxidant ma Fofo togafitiga

 

Tusitusiga masani