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Acacetin pauta (480-44-4)

Acacetin (5,7-dihydroxy-4-methoxyflavone) o se flavonoids e tupu mai i le natura, e iloa o loʻo i ai le tele o mea tau vailaʻau, e aofia ai le neuroprotective, cardioprotective, anticancer, anti-inflammatory, antidiabetic, and antimicrobial activities.

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Acacetin (5,7-dihydroxy-4-methoxyflavone) e salalau i le Malo o Laʻau, ae e sili ona tele i Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae ma Malvaceae aiga. Ua faʻaalia e faʻaalia ai le malosi o le faʻalavelave faʻasaga i le glutathione reductase, cyclo-oxygenase, acetylcholinesterase, aldose reductase ma xanthine oxidase enzymes.

 

Acacetin paʻu 480-44-4 Faʻamatalaga Faʻavae Faʻamatalaga

igoa Acacetin
CAS 480-44-4
Mama Atoatoa i Tulaga 98%
Igoa faʻapitoa 5,7-Dihydroxy-4′-methoxyflavone
Synonyms Acacetin, 480-44-4, 5,7-Dihydroxy-4′-methoxyflavone,4′-Methoxyapigenin
Faiga Faʻavae Molecular C16H12O5
Taumaʻa Masele 284.26 g / mol
Faaliusuavai 269 ° C
InChI Key DANYIYRPLHHOCZ-UHFFFAOYSA-N
faiga efuefu
Faʻaaliga Efuefu samasama
Afa o le Ola  
Solubility  
teuina o Meaai a Tuutuuga Faʻapipiʻi Tonu Pusa. Teu ese mai mea le talafeagai. Aveese uma mafuaʻaga o le sulu. Faleoloa I le Potu vevela
talosaga cosmetics, supplements, compactness pa'u
Pepa o suʻega iai

 

Acacetin pauta 480-44-4 Faamatalaga Aoao

Acacetin paʻu o mea mataʻutia o le Acacetin, o se O-methylated flavone e masani ona maua i fatu safflower ma nisi o laau e pei o Saussurea involucrata poʻo isi tagata o le aiga Asteraceae. I le aganuʻu muamua mesencephalic faʻaalia i le MPP +, o le acacetin na lipotia e puipuia ai sela dopaminergic, ma e fesoʻotaʻi ma le faʻaitiitia o le NO, prostaglandin E2, ma le TNF-α. E le gata i lea, o le togafitiga o le acacetin na tuʻuina atu i le MPTP-lesioned mice na faʻaleleia ai le le atoatoa o le afi na faʻaosoina e le MPTP ma puipuia sela dopaminergic i le striatum ma le SN. MPTP-faʻateleina le faʻamalosia o le microglia, e pei ona atagia mai i le maualuga o le iNOS ma le COX-2 faʻaaliga i le striatum ma le SN, na faʻaititia e le acacetin treatment.

 

Acacetin pauta 480-44-4 History

Acacetin (5,7-dihydroxy-4-methoxyflavone), o se vaega o meaʻai, e tele i le meli acacia ma e sili atu ana gaioiga faʻamaʻi. Acacetin, apigenin, chrysin, ma pinocembrin o flavonoid aglycones o loʻo maua i meaʻai e pei o le pasili, meli, seleni, ma le lauti chamomile. Flavonoids e mafai ona galue o ni mea'ai ma le iniseti o le enzyme CYP3A4, o le heme o loʻo i ai le enzyme e nafa ma le metabolism o le tasi vaetolu o vailaʻau i luga o le maketi.

 

Acacetin pauta 480-44-4 Mfaiga Of Afaʻasologa

Acacetin (5,7-dihydroxy-4-methoxyflavone) faʻaitiitia le gaosiga o le αβ e ala i le faʻalavelaveina o le BACE-1 gaioiga ma le faʻaogaina o le APP, e mafua ai le faʻaitiitia o le maualuga o vaega o le APP carboxy-terminal ma le APP intracellular domain. O le mea lea, o le puipuiga o le acacetin i luga o le gaosiga o le αβ o loʻo faʻasalalau e ala i tulafono faatonutonu o le BACE-1 ma le APP, e mafua ai le faʻaitiitia o le faʻaaliga o le porotini APP ma le gaioiga BACE-1. O le acacetin na faʻalavelaveina foi le faʻaogaina o le APP, e mafua ai le faʻaitiitia o le numera o le amyloid plaques.

 

Acacetin pauta 480-44-4 talosaga

1. Ose mea e mafai ona puipuia mai ma'i cardiovascular

Acacetin (5,7-dihydroxy-4′-methoxyflavone) o le vaega sili ona olaola o le vailaʻau faʻaSaina masani "Snow lotus". I le avea ai o se vailaʻau flavonoids faʻanatura, ua faʻaalia e iai ni aʻafiaga lelei faʻafomaʻi e pei o le anti-inflammatory, anticancer, ma le anti-obesity. Faatasi ai ma i latou, o lona sao taua i faʻamaʻi cardiovascular (CVD) ua maua le gauai tele mai tagata atamamai i tausaga talu ai nei.

 

2. Superior Antikanes Gaoioiga

Acacetin (5,7-dihydroxy-4′-methoxyflavone) o se vailaʻau flavonoid faʻatasi ai ma antimutagenic, antiplasmodial, antiperoxidant, anti-inflammatory and anticancer effects.

O suʻesuʻega e faʻaalia ai na taofia e le acacetin le faʻaogaina o sela DU145 e ala i le faʻaosoina o apoptosis. O suʻesuʻega i Sisifo o faʻailoga eseese o ala faʻailoga na faʻaalia ai o le acacetin e faʻatatau i le Akt ma le faʻainisinia (NF) -κB ala faʻailoga e ala i le taofiofia o le phosphorylation o le IκBα ma le NF-κB i se fua faʻalagolago. E ogatasi ma lona gafatia e faʻaosofia ai le apoptosis, o le acacetin-mediated inhibition of the pro-survival pathway, Akt, ma le auala NF-κB na faʻatasi ma se faʻaitiitia faʻailoga i le maualuga o le NF-κB-regulated anti-apoptotic proteins, Bcl-2 ma le X-sootai inhibitor o apoptosis porotini (XIAP), faapea foi ma le proliferative porotini, cyclooxygenase (COX)-2.

O le Acacetin e fa'aalia ai a'afiaga o le tumor e ala i le fa'atatauina o le ala fa'ailoga Akt/NF-κB.

 

3.Potentially faʻaaogaina anti-inflammatory ma antioxidative aafiaga i sepsis

Acacetin o se flavonoids masani e maua i laau eseese, e aofia ai Sparganii rhizoma, Sargentodoxa cuneata ma Patrinia scabiosifolia. O le Sepsis o se tali fa'aletonu fa'aletonu i fa'ama'i, ma e leai ni togafitiga lelei e maua. O suʻesuʻega ua faʻaalia ai o le acacetin e mafai ona faʻaaogaina ai le anti-inflammatory ma le antioxidative aafiaga ile sepsis.

 

4.A'afiaga acacetin ile fa'ama'i o le Alzheimer

O le fa'ama'i o le Alzheimer (AD) ose ma'i neurodegenerative ma o le tulaga sili ona taatele o le tu'inanau i atunu'u atia'e ma atina'e. O suʻesuʻega e faʻaalia ai o le acacetin e iai aʻafiaga lelei i le faʻamaʻi o le Alzheimer.

 

5. Anti-inflammatory / antinociceptive gaoioiga

Acacetin o se bioflavonoid faʻatasi ai ma mea tau vailaʻau e pei o gaioiga faʻamaʻi / anti-inflammatory. Peita'i, o fa'amaoniga fa'asaienitisi o lona fa'agaioiga o alaleo ma faiga fa'atino e le o iloa. O suʻesuʻega e faʻaalia ai o le acacetin e mafai ona aoga i togafitiga o faʻamaʻi faʻamaʻi.

 

Tusitaiala

1.Zhao, J; Dasmahapatra, AK; Khan, SI; Khan, IA (Tesema 2008). "Gaioiga Anti-aromatase o mea fa'avae mai damiana (Turnera diffusa)". Tusitala o Ethnopharmacology. 120 (3): 387–393. doi:10.1016/j.jep.2008.09.016. PMID 18948180.

2.Valkama, E; Salminen, JP; Koricheva, J; Pihlaja, K (2004). "Suiga i laulaau trichomes ma epicuticular flavonoids i le taimi o le tuputupu aʻe laulaau ile tolu birch taxa". Tala o Botany. 94 (2): 233–242. doi:10.1093/aob/mch131. PMC 4242156. PMID 15238348.

3. UmiKalsom, Iosefa; Harborne, Jeffrey B. (1991). “Flavonoid tufaina i asplenioid ferns”. Pertanika. 14 (3): 297–300.