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Sulforaphane efuefu (142825-10-3)

Sulforaphane pulu o se faʻataʻitaʻiga o meaʻai e maua mai i le isothiocyanate ma le tele o antitumor, chemopreventive ma togafitiga, e taofia le TPA-faʻamalosi NF-κB ma le COX-2 faʻaaliga i totonu o le MCF-10A ma le NAK-IKKβ. Sulforaphane pulu e mafai ona faia se taua o le neuroprotective i luga o le cholinergic defisit ma le afaina ai le mafaufau, o loʻo iai foʻi ma le anti-inflammatory اثر, a itiiti, i se vaega, e fesoʻotaʻi ma le faʻalavelave i le auala NF-κB.

Gaosiga: Faʻaputuga Gaosiga
afī: 1KG / ato, 25KG / talipalau
Wisepowder ei ai le gafatia e gaosia ma tuʻuina atu se aofaʻi tele. Gaosia uma i lalo o le cGMP tulaga ma faiga pulea lelei atoatoa, pepa uma suʻega ma faʻataʻitaʻiga avanoa.
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Sulforaphane efuefu (142825-10-3) vitio

 

Sulforaphane efuefu Base Faʻamatalaga

igoa Sulforaphane efuefu
CAS 142825-10-3
Mama Atoatoa i Tulaga 1% , 10%
Igoa faʻapitoa D, L-Sulforaphane
Synonyms sulforafan; sulforaphan; sulforaphane; R-SULFORAPHANE; R, S-SULFORAPHANE; SULFORAPHANE, L-; SULFORAPHANE, DL-; SULFORAPHANE, D-
Faiga Faʻavae Molecular I le C6H11NOS2
Taumaʻa Masele 177.3
Faaliusuavai 68.93 ° C (valoia)
InChI Key SUVMJBTUFCVSAD-UHFFFAOYSA-N
faiga efuefu
Faʻaaliga Lua i samasama
Afa o le Ola /
Solubility Chloroform (Faʻaavanoa), Methanol (Lemu laititi)
teuina o Meaai a Tuutuuga -20 ° C
talosaga Malosiʻaga, filifilia faʻapitoa o le vaega II detoxification enzymes ma anticarcinogenic meatotino. Tupu masani i le broccoli. Na maua e faʻafofoina ai le gaosia faʻamalosia susu o le susu lapisi i isumu. Antitumor sooupu.
Sulforaphane ua lipotia mai i se tamaʻi suʻesuʻega e foia ai auga e fesoʻotaʻi ma autism.
Pepa o suʻega iai

 

Sulforaphane Powder Lautele Faʻamatalaga

Sulforaphane, o loʻo tuueseeseina mai fatu o le Brassica oleracea L. var. botrytis L, o se faʻataʻitaʻiga o fualaʻau-maua mai isothiocyanate ma faʻamalieina chemopreventive ma togafitiga togafitiga. Sulforaphane efuefu ei ai antitumor aafiaga faasaga i sela kanesa sela e ala i se ROS-fefaʻatauaʻi intrinsic auala apoptotic, ma fautua mai o le faʻatuatuaga ER ma Nrf2 mafai ona fai ma sui o fuafuaga faʻatatau mo Sulforaphane-faaosofia apoptosis. Sulforaphane mafai ona faia se aafiaga taua o le neuroprotective i cholinergic mativa ma le malamalama. O loʻo ola i le pato Broccoli le tele o sulforaphane, o loʻo maua foi i isi togalaʻau pei o kapisi ma kale.

 

Sulforaphane Powder (142825-10-3) Talafaʻasolopito

Sulforaphane pulu o se isothiocyanate o loʻo i ai i le tele o taumafa fualaʻau; ua faʻaalia ni anticancer ma cardioprotective gaioiga.

I Vitro: Sulforaphane faʻatupuina se taamilosaga taofiga taofiofia i se fua-faalagolago auala, sosoo ai ma sela maliu. Lenei sulforaphane-faaosofia sela taofiga pue sa fesootaʻi ma le faateleina o faʻaaliga o afa A ma B1. Sulforaphane faʻaosofia le oti feʻaveaʻi i le apoptotic process. Sulforaphane e taofia ai le toe faʻafouina o le tuputupu ae ma faʻaititia le olaola feola i totonu o le gaʻo kolone carcinoma sela (HT29) ma o loʻo i ai se maualalo oona i luga esea CaCo2 sela. Muai togafitiga o H9c2 isumu myoblasts ma sulforaphane faʻaititia le numera apoptotic sela ma le faʻaaliga o le pro-apoptotic protein (Bax, caspase-3 ma cytochrome c), faʻapea foi ma le doxorubicin-mafuaʻaga faateleina i le mitokondrial membrane mafai. E le gata i lea, sulforaphane faʻateleina le mRNA ma porotini faʻaalia o le heme oxygenase-1, lea e faʻaitiitia ai le maualuga o le gaosia ituaiga okesene (ROS, fuaina faʻaaogaina MitoSOX Red reagent) i le mitochondria o loʻo faʻaosofia e doxorubicin.

I Vivo: Sulforaphane mafai ona poloka le fausiaina o vaega o le toto puipui i Sprague-Dawley isumu togafiti ma tasi ova o 9,10-dimethyl-1,2-benzanthracene. O le faʻatulagaina o le sulforaphane e faʻaititia ai le tutupu, faʻateleina, ma le mamafa ma le tolopoina o le atinaʻeina o meaola o le susu e ala i le na o le tasi le DMBA i fafine Sprague-Dawley.

 

Sulforaphane efuefu Mechanism Of Action

Biochem / Physiol Galuega

Filifili inducer o le vaega II detoxification enzymes ma anticarcinogenic meatotino. Organosulfur vaega o loʻo maua i fualaau oona, e aofia ai ma broccoli.

Sulforaphane o se aneti-kanesa, aneti-microbial ma aneti-maʻi suka maua ai fualaʻau faʻasaina o lo o maua ai. Sulforaphane foi faʻateleina le faʻaliliuga o le kanesa suppressor porotini ma taofia histone deacetylases. Na te faʻamatalaina ni faʻafitauli e ala i le faʻaleaogaina o le iNOS, COX-2, IL-1β ma le TNF-α e faʻaofia e le LPS.

 

Sulforaphane Powder (142825-10-3) Talosaga

Sulforaphane mafai ona puipuia le kanesa o le paʻu pe a tuʻuina saʻo i le paʻu. Sulforaphane o se malosi, faʻapitoa inducer o vaega II detoxification enzymes ma anticarcinogenic meatotino. Tupu masani i le broccoli. Na maua e faʻafofoina ai le gaosia faʻamalosia susu o le susu lapisi i isumu. Antitumor sooupu.
Sulforaphane ua lipotia mai i se tamaʻi suʻesuʻega e foia ai auga e fesoʻotaʻi ma autism.

 

Sulforaphane Powder (142825-10-3) Tele suʻesuʻega

Sulforaphane faʻaalia ni anticancer, antidiabetic, ma antimicrobial meatotino i faʻataʻitaʻiga faʻataʻitaʻi. E maua mai i le faʻaʻapipiina o fualaʻau pei o broccoli, Brussels totoga poʻo kapisi. O le enzyme myrosinase e suia le glucoraphanin, o le glucosinolate, i le sulforaphane i luga o le faʻaleagaina o le laʻau (pei o le lamuina). O laʻau talavou o broccoli ma kupula e tele lava lona tamaoaiga i le glucoraphanin.

 

Sulforaphane Powder (142825-10-3) Faʻasino

  • Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H.HBT1, Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Aloese mai Bell-Shaped Response in In Vitro BDNF Production. J Pharmacol Exp Ther. 2018 Mati; 364 (3): 377-389. doi: 10.1124 / jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.
  • Zhang, Y., et al .: Proc. Natl. Avea. Sai. ISA, 89, 2399 (1992), Shikita, M., et al .: Biochem. J., 341, 725 (1999), Wittich, S., et al: J. Med. Chem., 45, 3296 (2002), Lee, J., et al .: Cancer Lett., 224, 171 (2005); Fomaʻi ma Eng. Tala Fou, p 11, Oketopa 20 (2014)
  • Gamet-Payrastre L, 'ua al. Sulforaphane, o se natura tupu isothiocyanate, faʻaosofia le taamilosaga taofiga pueina ma apoptosis i HT29 tagata kolone kanesa sela. Kanesa Res. 2000 Mati 1; 60 (5): 1426-33.
  • Li B, 'ua al. Sulforaphane e puipuia ai le doxorubicin-faʻatupuina o le faʻamalologa o le mafaufau ma le sela maliu i isumu H9c2 sela. Int J Mol Med. 2015 Iulai; 36 (1): 53-64. [3]. Zhang Y, 'ua al. Anticarcinogenic gaioiga o sulforaphane ma faʻatautaiga faʻatatau synthetic norbornylisothiocyanates. Proc Natl Acad Sci US A. 1994 Aperila 12; 91 (8): 3147-50.
  • 2020 Glucoraphanin vs. Sulforaphane: Le sili Antioxidant ma Key Nutrient I Broccoli

 

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