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7,8-Dihydroxyflavone paʻu

7,8-Dihydroxyflavone, e taʻua foi o le tropoflavin, o se flavone masani e maua i Godmania aesculifolia, Tridax procumbens, ma laulaau o le primula tree.[2][3][4] Ua maua e galue o se agonist mole laiti malosi ma filifilia o le tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), o le faʻailoga autu o le faʻailoga o le neurotrophin faiʻai e maua mai le neurotrophic factor (BDNF). O le Tropoflavin e mafai ona tu'u tautala ma mafai ona ulu i le pa puipui o le toto-fai'ai. O se vailaʻau o le tropoflavin ma le faʻaleleia atili o le malosi ma le pharmacokinetics, R13 (ma, muamua, R7), o loʻo i lalo o le atinaʻeina mo togafitiga o le faʻamaʻi o le Alzheimer.

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7,8-Dihydroxyflavone paʻu Faʻamatalaga Faʻamatalaga Faʻamatalaga

igoa 7,8-DIHYDROXYFLAVONE
CAS 38183-03-8
Mama Atoatoa i Tulaga 98%
Igoa faʻapitoa 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Synonyms 7,8-DHF; 7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone; DIHYDROXYFLAVONE, 7,8-(RG); 7,8-Dihydroxyflavone hydrate; 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one; 8-Dihydroxyflavone; 7,8-DIHYDROXYFLAVONE 7,8-DIHYDROXYFLAVONE; 7,8-dihydroxy-2-phenyl-4h-1-benzopyran-4-on
Faiga Faʻavae Molecular C15H10O4
Taumaʻa Masele 254.24
Faailoga Boling 494.4 ° C i 760 mmHg
InChI Key COCYGNDCWFKTMF-UHFFFAOYSA-N
faiga malō
Faʻaaliga Yellow efulafu
Afa o le Ola /
Solubility DMSO : ≥ 100 mg/mL (393.33 mM)

Solu i le DMSO, ethanol, ma methanol.

teuina o Meaai a Tuutuuga potu faataitai
talosaga 7,8-Dihydroxyflavone o se TrkB agonist lea e taofia ai le glutamate-triggered apoptosis
Pepa o suʻega iai

 

7,8-Dihydroxyflavone paʻu Faʻamatalaga Lautele

7,8-Dihydroxyflavone (7,8-DHF) o se flavone monophenolic ma aʻafiaga eseese. E galue o se agonist o le neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), puipuia neurons e faʻaalia TrkB mai apoptosis.1 7,8-DHF o le neuroprotective i se manu faʻataʻitaʻiga o le maʻi o Parkinson.1 E lagolagoina aʻoaʻoga faʻalagona i isumu. ma toe faʻafoʻi le faaletonu o le mafaufau i se faʻataʻitaʻiga o le isumu o le faʻamaʻi o le Alzheimer.2,3 E faʻaleleia ai foi le gaioiga o le afi ma faʻalauteleina le ola i se faʻataʻitaʻiga manu o le maʻi a Huntington.4 7,8-DHF faʻalavelave le cytochrome P450 aromatase (IC50 = 10 μM) ma, i le auala lea, e suia ai le estrogen metabolism.5 E iai foʻi le gaioiga faʻamaʻi e faʻateleina ai le faʻaogaina o le glutathione intracellular ma faʻafefe ai ituaiga okesene faʻafefe.

 

7,8-Dihydroxyflavone paʻu Talafaasolopito

I le 2017, na fa'asalalau fa'amaoniga e ta'u mai ai o le tropoflavin ma le tele o isi fa'ama'i mole TrkB ua lipotia mai atonu e le o ni agonist tuusa'o o le TrkB ma e ono fa'atalanoaina o latou a'afiaga i isi auala.

 

7,8-Dihydroxyflavone pauta Mfaiga Of Afaʻasologa

O le 7,8-Dihydroxyflavone o se faʻamaʻi totoga o le tyrosine kinase B (TrkB). E fa'aalia uma a'afiaga o le neurotrophic factor e maua mai i le fai'ai (BDNF)—e pei o le puipuia o neu mai le apoptosis, fa'alavelaveina le o'ona e a'afia ai le kainic acid, fa'aitiitia le tele ole infarct ile stroke, ma le neuroprotecting i se manu fa'ata'ita'iga o le ma'i Parkinson-e aunoa ma le le lelei tala'aga pharmacokinetic o le BDNF fa'atapula'aina lona malosi fa'afoma'i.

7,8-Dihydroxyflavone (7,8-DHF) e mafai ona faʻaaogaina e fesoasoani e faʻamaonia ma faʻaeseese ai aʻafiaga o le tino ma ala faʻailoga e faʻasalalau e le TrkB activation, e pei o mea e aʻafia ai, manatua, vasorelaxation ma le toto maualuga. 7,8-DHF e maua ai le puipuiga i le scopolamine fa'aosoina Alzheimer-pei o pathologic faaletonu.

 

7,8-Dihydroxyflavone powder Application

7,8-Dihydroxyflavone hydrate ua faʻaaogaina e pei o le tropomyosin-receptor-kinase B (TrkB) agonist i isumu ma faʻalavelave ai le TrkB mo le mataʻituina o galu postsynaptic faʻaosofia (eEPSCs).

 

7,8-Dihydroxyflavone powder Sili atu suʻesuʻega

O le tele o faʻataʻitaʻiga vavalalata o le tropoflavin ua maua foʻi e avea ma TrkB agonists in vitro, e aofia ai le diosmetin (5,7,3′-trihydroxy-4′-methoxyflavone), norwogonin (5,7,8-trihydroxyflavone), eutropoflavin. (4'-dimethylamino-7,8-dihydroxyflavone), 7,8,3'-trihydroxyflavone, 7,3'-dihydroxyflavone, 7,8,2'-trihydroxyflavone, 3,7,8,2'-tetrahydroxyflavone, ma 3,7-dihydroxyflavone.[37] O le maualuga hydroxylated analog gossypetin (3,5,7,8,3′,4′-hexahydroxyflavone), i se isi itu, e foliga mai o se tagata tetee o TrkB in vitro.

Na maua foi le Tropoflavin e faʻaitiitia ai le moe o isumu i le vaega pogisa ma faʻaititia le maualuga ole hypothalamus ole orexin A ae le o le orexin B ile isumu.

 

Tusitaiala

  1. Andero et al (2012) 7,8-dihydroxyflavone, o le TrkB receptor agonist, poloka le faʻaleagaina o mafaufauga faʻaleaganuʻu umi e mafua mai i le immobilzation stress i isumu. Hippocampus 22 399
  2. Jang et al (2010) O se agonist TrkB filifilia ma gaioiga malosi neurotrophic e 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268
  3. Boltaev U, Meyer Y, Tolibzoda F, Jacques T, Gassaway M, Xu Q, Wagner F, Zhang YL, Palmer M, Holson E, Sames D (2017). "O su'esu'ega fa'afuainumera tele e fa'ailoa mai ai le mana'omia o le toe iloiloina na lipotia mai o agonists TrkB la'ititi la'ititi". Sci Signal.
  4. Jiang Small-molecule TrkB receptor agonists faʻaleleia le gaioiga afi ma faʻalautele le ola i se faʻataʻitaʻiga o isumu o le maʻi o Huntington. Hum.Mol.Genet. 2013