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Nicotinamide Riboside Chloride pauu (23111-00-4)
Nicotinamide Riboside Chloride pou vitio
Nicotinamide Riboside Chloride efuefu (23111-00-4) Faʻavae Faʻamatalaga
| igoa | Nicotinamide Riboside Chloride pauu |
| CAS | 23111-00-4 |
| Mama Atoatoa i Tulaga | 98% |
| Igoa faʻapitoa | 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride |
| Synonyms | Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, α / β paluga |
| Faiga Faʻavae Molecular | C11H15ClN2O5 |
| Taumaʻa Masele | 290.7 g / mol |
| Melting Point | 115 ℃ -125 ℃ |
| InChI Key | YABIFCKURFRPPO-FSDYPCQHSA-N |
| faiga | malō |
| Faʻaaliga | Paʻe Paʻepaʻe i le Pale samasama pauta |
| Afa o le Ola | 2.7 itula |
| Solubility | Soluble i le DMSO |
| teuina o Meaai a Tuutuuga | Faʻamago, pogisa ma i le 0 - 4 C mo se taimi puʻupuʻu (aso i vaiaso) poʻo le -20 C mo se taimi umi (masina i tausaga). |
| talosaga | Nicotinamide riboside o se pyridine-nucleoside ituaiga o vaitamini B3. |
| Pepa o suʻega | iai |
Nicotinamide Riboside Chloride paula (23111-00-4) Faʻamatalaga Lautele
O le Nicotinamide Riboside Chloride powder nucleosides o loʻo muamua mai i le nikotinamide adenine dinucleotide (NAD) ma fai ma sui o se puna o le vitamini B3. Talu ai nei suʻesuʻega ua faʻaalia ai o le avea o se sili atu aofaʻi o nikotinamide nucleosides e masani ona iai i meaʻai e mafai ona maua ai ni soifua maloloina fou. Mo se faʻataʻitaʻiga, o le nikotinamide nucleosides ua aʻafia i le faʻateleina o aano o le tino NAD faʻatosinaina ma faʻamalosia le inisene lagona faʻapea foi ma le faʻaleleia atili o le sirtuin function. O lona agavaʻa e faʻateleina ai le gaosiga o le NAD o loʻo fautua mai ai o le nikotinamide nucleosides e mafai foi ona faʻaleleia le soifua maloloina mitochondrial, faʻaosofia ai le mitochondrial function, ma faʻatosinaina le gaosiaina o mitochondria fou. O isi suʻesuʻega e faʻaaogaina ai nikotinamide nucleosides i le faʻamaʻi o le Alzheimer ua faʻaalia ai o le molemole e mafai ona maua i le faiʻai ma ono maua ai le neuroprotection e ala i le faʻaosofia o le faiʻai o le NAD synthes.
Nicotinamide Riboside Chloride History
I le 2012 suʻesuʻega na matauina o isumu fafaga se maualuga-gaʻo meaʻai faʻaopoopo faʻatasi ma nicotinamide nucleosides sa i ai le 60% faʻaititia o le mamafa faʻatusatusa i faʻatusa o isumu fafaga tutusa lava gaʻo meaʻai e aunoa ma nicotinamide nucleoside.
I le avea ai o se vailaʻau faʻamalosi, o le doxorubicin o se tasi o vailaʻau aoga o le chemotherapeutic e sili ona aoga ma lautele i le togafitia o ituaiga eseese o tuma mautu. Ae paga lea, mo le tele o tausaga, o lona fatuʻioto i togafitiga o le kanesa ua faʻatapulaʻaina ai le faʻaogaina o le vailaʻau.
Nicotinamide Riboside Chloride Mechanism O Gaoioiga
Nicotinamide Riboside (NR) o se ituaiga o vitamini B3 na maua talu ai nei, e mafai ona faʻateleina ai le maualuga o Nicotinamide Adenine Dinucleotide (NAD +) tulaga i tagata.
NAD + o se ki-co-enzyme o le mitochondria i sela uma o tatou tino e faʻalagolago i ai e faʻatumuina uma galuega taua.
Ole tulaga pau ile NAD + a o tatou matutua ma ile taimi e faʻapopoleina ai o tatou tino ile faʻamaʻi poʻo le pupuga masani.
Niacinamide o se vaega o le coenzyme I ma coenzyme II, avea o le coenzyme o le tele dehydrogenases.
I meaʻai gaosi, o nicotinamide o loʻo faʻaoga faʻatasi ma Vc o se lanu muamua
Niacin e taua foi o le vitamini B3, poʻo vitamini PP, Niacin e taua foi o le nicotinic acid ma niacin. Ole tino o le tagata e aofia ai foi lona faʻatonuga nicotinamide poʻo le nicotinamide. O se tasi o le 13 vitamini talafeagai mo le tino o le tagata, o se vai-solomago vitamini, o le aiga B o vitamini B. mānava o le faʻamama faʻasolosolo ma le faʻagasologa o anaerobic faʻateʻa suka.
Nicotinamide Riboside Chloride Talosaga
O mea na tupu muamua mai faʻataʻitaʻiga na faʻaalia ai o le faʻaopopoina o le nicotinamide ribose e le gata e mafai ona faʻateleina le tulaga o le NAD +, ae ia faʻateleina le faʻaaogaina o le NAD + i tagata, e le mafai i isi vitamini B3. tino vave suia i avea NAD +. O nei NAD + ona faʻamalosia ai lea o le gaioiga o intracellular amataina o le malosi gaosi e mitochondria
Nicotinamide Riboside Chloride mafai faʻaleleia mitochondrial gaioiga, lea o loʻo faʻaalia e faʻalauteleina ai le faʻaaliga o mitochondrial electron transport chain proteins, faʻalauteleina mitochondrial membrane gafatia, ma faʻateleina le fua faatatau o oxidative manava ma intracellular ATP tulaga. E mafai ona o faʻatasi ma le maualuga maualuga o le toe faʻafouina ole mitochondrial. Mitochondrial function e faʻasolo ina ua tatou matutua, ma o le faʻailoga lea o le matua o sela sela na tatou maua. NR mafai faʻalauteleina le gaioiga o mitochondria ma taofia le senescence o sela sela.
Nicotinamide Riboside Chloride Nisi suesuega
Nicotinamide nucleosides o ni mea muamua o le nicotinamide adenine dinucleotide (NAD) ma e fai ma sui o le punavai o vitamini B3. O suesuega talu ai nei na faʻaalia ai o le aveina o le tele o nicotinamide nucleosides e masani ona iai i meaʻai e mafai ona maua ai ni penefiti fou mo le soifua maloloina. Mo se faʻataʻitaʻiga, nicotinamide nucleosides na aafia ai i le faʻateleina o le tino NAD ma faʻamalosia le inisalini ma faʻalauteleina le sirtuin function. O lona agavaʻa e faʻateleina ai le gaosiga o le NAD faʻaalia ai o nicotinamide nucleosides e mafai foi ona faʻaleleia ai le soifua maloloina o le mitokondria, faʻamalosia le mitokondria galuega, ma faʻaosofia ai le gaosiga o mitochondria fou. O isi suʻesuʻega e faʻaogaina ai nicotinamide nucleosides i le faʻamaʻi o le Alzheimer ua faʻaalia ai o le moli o mea e avanoa i le faiʻai ma e ono maua ai le neuroprotection e faʻaosofia ai le faiʻai o le NAD synthesis.
O le Nicotinamide Riboside Chloride e mafai foi ona faʻaititia ai le mamafa: Ua faʻaalia i suʻesuʻega le faʻateleina o le malosi o le tino, e mafai ai ona faʻaititia lelei le maualuga o le gaʻo o meaʻai. Ina ia mafai ona iloilo le nikotinamide ribose auala o le NR faʻalauteleina le paʻu o le mamafa, na fuaina ai e le au suʻesuʻe le gaioiga mitochondrial e fesoʻotaʻi ma le taumafaina o kalori, gaioiga, kalori, taamilosaga o le sulugatiti, malologa metabolic rate, tino tuufaatasiga, glucose faʻapalepaleina, inisula lagona ma isi biochemical ma metabolomics tapulaʻa Nei faʻamaumauga ma le fou paʻu leiloa auala e ala i le malabsorption, excrption o meaola faʻailoga mo le sailia. Na lipotia mai e le au suʻesuʻe, o isumu na fafagaina le nikotinamide nicotinamide supplement e foliga mai e tele atu le paʻu e faatatau i isumu e leʻi faaopoopoina i le nikotinamide
Nicotinamide Riboside Chloride Tusi Faasino
- Chi Y, Sauve AA. Nicotinamide riboside, o se vaega taua i meaʻai, o le vitamini B3 ma aʻafiaga i le malosi metabolism ma le neuroprotection. Curr Opin Clin Nutr Metab Tausiga. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Iloilo. PubMed PMID: 24071780.
- Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: o se iloiloga o le NAD + muamua o vitamini i taumafa o tagata. Faʻasalalauga Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Iloilo. PubMed PMID: 18429699.
- Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein protein Crit Rev Biochem Mol Vaʻa. 2013 Nov-Tesema; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Iloilo. PubMed PMID: 24050258; PubMed Tutotonu PMCID: PMC4113336.
- Yang Y, Sauve AA. NAD (+) metabolism: Bioenergetics, faailo ma togafiti mo togafitiga. Ava ole Biochim Biophys. 2016 Tesema; 1864 (12): 1787-1800. doi: 10.1016 / j.bbapap.2016.06.014. Iloilo. PubMed PMID: 27374990.
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