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Coluracetam paula (135463-81-9)

Coluracetam paula, ua taʻua foi o BCI-540; MKC-231, o le AMPA receptor agonist e ono aoga mo le togafitiga o le tele o le atuatuvale ma le atuatuvale. MKC-231 feteʻenaʻi i le phencyclidine-faʻatupuina amioga le lava ma le faʻaititia o le septal cholinergic neurons i isumu. MKC-231 faʻalelei faʻamalolosi le le lava o faʻamanatuga ma le faʻaititia o le hippocampal acetylcholine na faʻatupuina e le ethylcholine aziridinium ion i isumu.

Gaosiga: Faʻaputuga Gaosiga
afī: 1KG / ato, 25KG / talipalau
Wisepowder ei ai le gafatia e gaosia ma tuʻuina atu se aofaʻi tele. Gaosia uma i lalo o le cGMP tulaga ma faiga pulea lelei atoatoa, pepa uma suʻega ma faʻataʻitaʻiga avanoa.
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Coluracetam paula (135463-81-9) vitio

 

Coluracetam efuefu Base Faʻamatalaga

igoa Coluracetam laupepa
CAS 135463-81-9
Mama Atoatoa i Tulaga 98%
Igoa faʻapitoa N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide

FA-231-LE

e-540

Synonyms Coluracetam; BCI-540; MKC-231; TLM 540; MKC 231; BCI540; MKC231.
Faiga Faʻavae Molecular C19H23N3O3
Taumaʻa Masele 341.411 g / mol
Melting Point
InChI Key PSPGQHXMUKWNDI-UHFFFAOYSA-N
faiga Paʻu paʻu
Faʻaaliga paʻu paʻepaʻe paʻepaʻe
Afa o le Ola
Solubility Soluble i le DMSO
teuina o Meaai a Tuutuuga Faʻamago, pogisa ma i le 0 - 4 C mo se taimi puʻupuʻu (aso i vaiaso) poʻo le -20 C mo se taimi umi (masina i tausaga)
talosaga Coluracetam (MKC-231) o se vailaau racetam synthetic ua taua o se nootropic lotoa. E leai se tino tele o molimau o loʻo suʻesuʻeina, ae peitaʻi o mea o loʻo faia e pei o le racetam e pei o Piracetam poʻo Aniracetam.
Pepa o suʻega iai

 

Coluracetam paʻu Lautele Faamatalaga

Coluracetam paula, ma le CAS 135463-81-9, ua faʻaigoaina foʻi BCI-540 ma MKC-231. Coluracetam na fausiaina i Iapani ma na faatoa lesitala i le 2005 e le Mitsubishi Tanabe Pharmaceutical Corporation, ona faʻasolo mai ai lea o lona tulaga i BrainCells Inc.

Coluracetam paula o se faiʻai faʻapipiʻi mo faʻaleleia atili o le mafaufau, faʻaleleia o le mafaufau faʻapea foi ma le togafitia tele Major Depressive Disorder (MDD) ma faʻafitauli popolega.

 

Coluracetam paula (135463-81-9) Talafaʻasolopito

Coluracetam (INN) (code name BCI-540; muamua MKC-231) paʻu o se nootropic sooupu o le racetam aiga. Na muamua atiaʻe ma faʻataʻitaʻia e le Mitsubishi Tanabe Pharma Corporation mo le faʻamaʻi o le Alzheimer. I le maeʻa ai o le vailaʻau le manuia e oʻo atu i faʻaiuga o ana falemaʻi faʻataʻitaʻi sa laiseneina e BrainCells Inc mo suʻesuʻega i le tele o faʻanoanoaga faʻaletonu (MDD), lea na muamua atu i le faʻailogaina o le "Qualifying Therapeutic Discovery Program Grant" e le setete o Kalefonia.

Sailiga mai le vaega IIa faʻataʻitaʻiga faʻataʻitaʻiga ua fautua mai o le a avea ma se vailaʻau gafatia mo comorbid MDD ma faʻafitauli lautele popole (GAD). O le BrainCells Inc o loʻo i ai nei [o afea?] Laiseneina le vailaʻau mo lenei mafuaʻaga. [Atoa e manaʻomia] E ono i ai foi ni aʻoga e ono i ai i le puipuia ma le togafitia o ischemic retinopathy ma le retinal ma optic saraf manuʻa.

Coluracetam ua faʻaalia e faʻaleaogaina le leiloa o le kolini acetyltransferase gaosiga i le ogatotonu ogatotonu o namu o le maʻa e faʻaalia i phencyclidine (PCP), ma ua manatu o se vailaau fofo togafitiga mo le schizophrenia.

 

Coluracetam (135463-81-9) Faʻatino o gaioiga

Coluracetam faʻalauteleina le maualuga-vavalalata faʻamalosia choline uptake (HACU), o le fua faatatau-faʻatapulaʻa laʻasaga o acetylcholine (ACh) synthesis. O suʻesuʻega ua faʻaalia ai le coluracetam ia faʻaleleia atili le faʻaleaogaina o le aʻoaʻoina i luga o le tasi fualaʻau tui tuʻuina atu i isumu ua aafia i cholinergic neurotoxins. O suʻesuʻega na faia mulimuli ane, na faʻaalia ai e ono faʻaosofia ni aʻafiaga umi na maua i le cholinergic neurotoxin-treated rats e ala i le suia o le choline transporter tulafono faʻatonutonu.

 

Faamanuiaga o Coluracetam (135463-81-9)

Coluracetam o se nootropic lotoa i le aiga racetam, faatasi ai ma se tulaga faʻateleina faʻateleina aafiaga i luga aʻafia maualuga luga kolini.
Coluracetam mafai faaleleia le manatua, aʻoaʻoina, popolevale, tūlaga faigatā, ma le vaʻai. E i ai ono faʻaaogaina i le puipuia ma togafitiga o ischemic retinopathy ma retinal ma optic neura manua. E mafai foi ona faʻaleleia atili le aʻoaʻoina o faʻafitauli i luga o le tasi fualaʻau tui tuʻuina atu i isumu ua aafia i cholinergic neurotoxins.
E mafai ona faʻaosofia ai le umi o le gaioiga faʻamaonia i le cholinergic neurotoxin-togafiti togafiti e ala i le suia o le koline transporter tulafono faatonutonu faiga. Ole Coluracetam o loʻo faʻaalia e faʻaleleia atili le gaioiga a le AMPA, o se gaioiga e faʻatupu ai le mafaufau ma le mataala.

 

Coluracetam (135463-81-9) itu itu

E le gata i lea, o tulaga masani ole racetam itu aoga e aoga foi mo tagata faʻaaoga Coluracetam. O nisi tagata e tauivi ma se ulu tiga ona o le leai o se acetylcholine (fofo e le alpha GPC po o le citicoline). O isi tagata e maua Colurracetam itu afaina e pei o overstimulation po o le fiafia, mimilo, po o le le fiafia.

 

Coluracetam (135463-81-9) Faʻamatalaga

  • Takashina K, Bessho T, Mori R, Kawai K, Eguchi J, Saito K. MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the boost of high-affinity affake. J Neural Transm (Vienna). 2008 Iulai; 115 (7): 1037-46. doi: 10.1007 / s00702-008-0049-0. PubMed PMID: 18461273.
  • Bessho T, Takashina K, Eguchi J, Komatsu T, Saito K. MKC-231, a choline-uptake enhancer: (1) umi le umi o le faʻaleleia atili o le mafaufau pe a maeʻa ona toe faʻauia i AF64A-togafiti togafiti. J Neural Transm (Vienna). 2008 Iulai; 115 (7): 1019-25. doi: 10.1007 / s00702-008-0053-4. PubMed PMID: 18461272.
  • Takashina K, Bessho T, Mori R, Eguchi J, Saito K. MKC-231, o se vailaʻau faʻaauau le faʻaaogaina o le koline: (2) Aafiaga i le tuufaatasia ma le faamatuu atu o le acetylcholine i isumu na togafitia AF64A. J Neural Transm (Vienna). 2008 Iulai; 115 (7): 1027-35. doi: 10.1007 / s00702-008-0048-1. PubMed PMID: 18446264.
  • Shirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R. Mulimuli ane le faʻaalia i le faʻaauau le gaʻo faʻaleleia MKC-231 e feteʻenaʻi le phencyclidine-faaosofia amioga amio ma faʻaititia o septal cholinergic neurons i isumu. Eur Neuropsychopharmacol. 2007 Setema; 17 (9): 616-26. PubMed PMID: 17467960.
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