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Oleoylethanolamide (OEA)

Oleoylethanolamine (OEA) o se lipano ethanolamide o loʻo tupu fua ma o se mea e tupu i totonu o le peroxisome. E gaosia i le laʻitiiti laititi ma taofia le taumafaina o taumafa e ala i le PPAR-α faʻagaioiga. OEA foi e faʻaaogaina le GPR119, o le lipactive bioactive ma faʻafitauli hypophagic ma anti-obesity.

Gaosiga:  Gaosiga o faʻaputuga
afī: 1KG / ato, 25KG / talipalau
Wisepowder ei ai le gafatia e gaosia ma tuʻuina atu se aofaʻi tele. Gaosia uma i lalo o le cGMP tulaga ma faiga pulea lelei atoatoa, pepa uma suʻega ma faʻataʻitaʻiga avanoa.
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Oleoylethanolamide (111-58-0) vitio

 

 

Oleoylethanolamide (111-58-0) Faʻamatalaga Faʻavae

igoa Oleoylethanolamide
CAS 111-58-0
Mama Atoatoa i Tulaga 85%, 98%
Igoa faʻapitoa N-Oleoylethanolamide
Synonyms N-Oleoylethanolamine, N- (Hydroxyethyl) oleamide, N- (cis-9-Octadecenoyl) ethanolamine, OEA
Faiga Faʻavae Molecular C20H39NO2
Taumaʻa Masele 325.53
Melting Point 59-60 ° C (138-140 ° F; 332-333 K)
InChI Key BOWVQLFMWHZBEF-KTKRTIGZSA-N
faiga malō
Faʻaaliga Paʻepaʻe papaʻe
Afa o le Ola /
Solubility H2O: <0.1 mg / mL (le faʻaolaina); DMSO: 20.83 mg / mL (63.99 mM; Manaʻomia le ultrasonic
teuina o Meaai a Tuutuuga -20 ° C
talosaga N-Oleoylethanolamine ua faʻaaogaina e suʻesuʻe ai ona aʻafiaga i glukagon-pei peptide (GLP) -1RA-faʻalauaʻitele anorectic faailoilo ma mamafa leiloa.
Pepa o suʻega iai

 

Oleoylethanolamide (111-58-0) Faʻamatalaga Lautele

OEA o se maualuga faʻatulagaina metabolite o le suauʻu olive. O le RiduZone na fuafuaina e faʻaaoga lelei meaʻai o le mediterania ma fesoasoani i le lagolagoina o le paʻu o le pauna.

RiduZone (OEA Capsule) ua taliaina e le FDA o se meaʻai fou mea faʻaopoopo.

Ole OEA ose tulafono faʻatonutonu mo meaʻai, mamafa ma gaʻo.

Oleoylethanolamide (OEA) o se metabolite masani lea e faia i ni tamaʻi laʻititi i lou laʻau laiti. OEA fesoasoani e faʻatonutonu le fiaʻai, mamafa, gaʻo tino ma kolose e ala i le fusifusia i se talipupuni ua lauiloa o PPAR-Alpha (Peroxisome proliferator-activate receptor alpha). O lona uiga, OEA e faʻateleina le metabolism o le gaʻo o le tino ma faʻailoa i lou faiʻai o oe ua tumu ma ua oʻo i le taimi e taofi ai le 'ai. O loʻo iloa foi le OEA e faʻateleina le le faia o ni kalori i le faamalositino.

 

Oleoylethanolamide (111-58-0) History

Ole gaioiga ole Oleoylethanolamide na maua i le 50 tausaga talu ai. I luma o le 2001, e leʻi tele se suʻesuʻega i le OEA. Peitai, i lena tausaga, Sipaniolo suʻesuʻe na taʻe le lipid ma suesue pe faʻapefea ona fai, pe o fea na faʻaaogaina ma pe o le a foi. Sa latou faʻataʻitaʻia le aafiaga o le OEA i le faiʻai (o isumu) e ala i le tuiina tuusaʻo i totonu o le faiʻai ventricles. Latou te leʻi mauaina se aʻafiaga i le 'ai ma faʻamaonia e le gaoioi le OEA i le faiʻai, ae o loʻo faʻatulagaina e se isi siama faʻailo e aʻafia ai le fia ai ma le taumafa.

 

Oleoylethanolamide (111-58-0) Faiga o Gaioiga

I le faigofie, oleoylethanolamide galue o se fiaʻai faʻatonutonu. E mafai e le OEA ona pulea lau taumafataga o meaʻai i le fai atu i le faiʻai o le tino ua tumu, ma e leai se isi meaʻai e manaʻomia. E le taumafa i mea uma i aso uma, ma atonu e le ova tele lou tino ile taimi umi.

O gaioiga e faʻatonutonu ai le maʻi o le oleoylethanolamide (OEA) e pei ona faʻaalia e le ata. OEA o loʻo faʻaogaina ma faʻapipiʻiina i totonu o le puʻeleʻele laʻititi mai le gaʻoa o le oleic e maua mai i meaʻai maua, pei o suauʻu olive. O meaʻai e maualuga le gaʻo e mafai ona taofia le gaosia o le OEA i le gaʻau. OEA faʻaititia meaai taumafa e ala ile faʻafaigaluegaina homeostatic oxytocin ma histamine faiʻai matagaluega faʻatasi ai ma le hedonic dopamine auala. E iai faʻamaoniga o le OEA e mafai foi ona faʻaititia le hedonic cannabinoid receptor 1 (CB1R) faʻailoga, o le faʻamalosiina o loʻo fesoʻotaʻi ma le faʻateleina o taumafa taumafa. OEA faʻaititia lipid felauaiga i adipocytes e faʻaititia ai gaʻo lapoʻa. O le faʻalauteleina o le faʻamalamalamaga o aʻafiaga o le OEA i meaʻai taumafa ma lipid metabolism o le a fesoasoani i le faʻatulagaina o le faʻatinoina o faʻamalositino e mafai ona fuafua e atiaʻe sili atu aoga togafitiga o maʻi suka.

OEA e galue e faʻatonutonuina se mea e taua PPAR ma faʻapena ona faʻamalieina le gaʻo-susunuina ma faʻaititia le gaʻo teuina. A e 'ai, ua maualuga le maualuga o le OEA ma ua faʻaititia lou fia' ai pe a fai e le iloa o neula o loʻo fesoʻotaʻi i lou faiʻai ua e tumu. PPAR-α o se vaega o ligand-faʻamalosia faaniukilia taliuni lea e aofia ai i le kenera faʻamatalaga o lipid metabolism ma energyhomeostasis auala.

OEA o loʻo faʻaalia uma uiga taua ole vaega ole satiety:

(1) E taofia le fafagaina e ala i le faʻaumiumi le malologa i le isi meaʻai;

(2) O lona tuufaatasiga faʻatonutonuina e taumafa maua ma

(3) O ona tulaga e i ai liʻo faʻaletagata.

 

Oleoylethanolamide (111-58-0) Talosaga

N-Oleoylethanolamide o se mea tiga o le peroxisome proliferator-activate receptor-α (PPAR-α). N- Oleoylethanolamide gaosia se faʻailoga i totonu o le tino e faʻamalosia ai le totonugalemu o le gaioiga dopamine faʻavaeina se fesoʻotaʻiga i le va o kalori- homeostatic ma hedonic- homeostatic Controllers. Oleoylethanolamide o loʻo aafia i le moli o faʻafoliga o loʻo fesoʻotaʻi ma le gastric bypass manuia. N- Oleoylethanolamide o se mea filifilia GPR55 agonist.

 

Oleoylethanolamide (111-58-0) Tele suʻesuʻega

I se tasi suʻesuʻega, e limasefulu (n = 50) tagata mataʻupu o loʻo manaʻo e faʻaitiitia le mamafa na fautuaina e ave le OEA 2-3 taimi / aso, 15-30 minute ae leʻi faia le taumafataga mo le 4-12 vaiaso. O mataupu e aofia ai i latou e leʻi faʻaaogaina oloa leiloa o le mamafa, i latou na oʻo i mea leaga na tutupu ma isi paʻu paʻu oloa, i latou na paʻu paʻu paʻu i luga o isi mamafa paʻu sui e pei o phentermine, i latou o taumafai e faʻaogaina suiga o le olaga olaga (vaega pule ma faamalositino masani ), ma i latou o loʻo togafitia lelei mo tulaga faʻafomaʻi e aofia ai le afaina o le suka i le suka, dyslipidemia, toto maualuga ma maʻi fatu.

I se suʻesuʻega lona lua, e 4 mataupu ma paʻu fuainumera 229, 242, 375 ma le 193 lbs, faʻatonuina e ave le Oleoylethanolamide capsules (tasi lea pusa e aofia ai 200mg 90% OEA). O mataupu sa ave ni 4 kapsula (1 kapsula 15-30 minute aʻo leʻi taumafataga ma e tatau ona latou ave se isi laupepa aʻo leʻi faia le latou taumafataga tele o le aso) i aso uma mo aso 28. O le mataupu mulimuli na muamua faatino lapisi vaega faʻapipiʻi. O mataupu sa faʻatonuina ia aua neʻi faia ni suiga ia latou meaʻai ma faamalositino masani.

 

Oleoylethanolamide (111-58-0) Faʻamatalaga

  • Sasso, O., et. al .: Tiga, 154, 350 (2013); Begg, DP, Woods, SC: Cell Met., 18, 459 (2013); Chem. ma Eng. Tala Fou p.7, Ianuari 8 (2017)
  • Gaetani S, Oveisi F, Piomelli D (2003). "Faʻatulagaina o taumafataga faʻataʻitaʻiga i le isumu e le anorexic lipid mediator oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311– doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Faʻatonutonuina o meaʻai faʻaaogaina e le oleoylethanolamine". Sela Mol. Olaga Sci. 62 (6): 708– doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Oleoylethanolamide (OEA): O se fualaʻau e leiloa le mamafa lea e fesoasoani i le puleaina o le fiaʻai

 

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