Alepha-lipoic Acid paula (1077-28-7)

Faamatalaga ole Alpha-lipoic Acid paula

igoa	Laupepa efuefu alfa-lipoic
CAS	1077-28-7
Mama Atoatoa i Tulaga	98%
Igoa faʻapitoa	(+/-) - 1,2-Dithiolane-3-pentanoic Acid; (+/-) - 1,2-Dithiolane-3-valeric Acid; (+/-) - Alpha-lipoic Acid / Thioctic acid; (RS) -a-Lipoic Oʻona
Synonyms	DL-Alpha-lipoic Acid / Thioctic acid; Liposan; Lipothion; NSC 628502; NSC 90788; Protogen A; Thioctsan Tioctacid;
Faiga Faʻavae Molecular	C8H14O2S2
Taumaʻa Masele	206.318 g / mol
Melting Point	60-62 ° C
InChI Key	AGBQKNBQESQNJD-UHFFFAOYSA-N
faiga	malō
Faʻaaliga	Malamalama Samasama i le samasama
Afa o le Ola	30 minute i le 1 itula
Solubility	Soluble i Chloroform (Lemu laʻititi), DMSO (Laulelei), Methanol (Lemu laʻititi)
teuina o Meaai a Tuutuuga	Faʻamago, pogisa ma i le 0 - 4 C mo se taimi puʻupuʻu (aso i vaiaso) poʻo le -20 C mo se taimi umi (masina i tausaga).
talosaga	O le gaʻo-metabolism stimulator.
Pepa o suʻega	iai
Alpha-lipoic oona Ata pauta

O le a le Alpha-lipoic Acid?

O le Alpha-lipoic acid o se vailaʻau e maua mai i le caprylic acid. O isi igoa o le ALA, lipoic acid, Biletan, Lipoicin, Thioctan, ma isi lona igoa vailaʻau o le 1,2-dithiolane-3-pentanoic acid poʻo le thioctic acid. O se vaega o le organosulfur ma e gaosia i le tino o tagata ma manu. O lona gaosiga e tupu mai le octanoic acid ma le cysteine ​​e avea ma punaoa o le sulfur. O se taua mea taua mo aerobic metabolism i le tino. O loʻo iai i sela uma ma fesoasoani e faʻatupu le malosi mai le kulukose.

E tele ana sela ma molemoli gaioiga, ona o ona antioxidant agavaʻa. O lenei gaioiga faʻamalosia o le alpha-lipoic acid ua faʻateleina lona fiafia e faʻaaoga e avea o se faʻaopoopoga o meaʻai. O loʻo faʻaaogaina foi o se sui sooupu mo togafitiga. Atonu o se togafitiga talafeagai ile maʻi suka, paʻu ole pauna, neuropathy mafua mai ile maʻi suka, manuʻa faʻamalolo, faʻalelei tulaga paʻu, ma isi.

O le Alefa-lipoic acid efuefu ei ai le afa-ola o le 30 minute i le tasi itula. E fai sina soluble ile chloroform, dimethyl sulokside (DMSO), ma le methanol. E mafai ona maua mai i spinach, fefete, broccoli, pateta, aano e pei o le ate ma fatugaʻo.

Ole aofaʻi maualuga e mafai e se tagata matua ona inu ile aso e 2400mg.

Faʻafefea ona galue le Alpha-lipoic Acid?

Alpha-lipoic acid o loʻo i ai ni vailaʻau faʻamalosi tino. O lona uiga e mafai ona malosi faʻamalosia e faasaga i le saoloto radicals i le tino ma faʻatelegese mea tutupu e pei o sela sela ma fesoasoani e faʻamalosia sela maloloina.

E gaosia i totonu o le mitochondria ma galue o se taua cofactor mo le talepeina i lalo enzymes ma niuterene. E chelates foi le metala uʻamea ma faʻaititia le oxidized ituaiga o isi antioxidants pei o vitamini C, Vitamini E, ma glutathione. E mafai foi ona toe faʻafouina latou.Alpha-lipoic acid e talafeagai mo le faʻatonutonuina o le reactive oxygen ituaiga.

O le Alpha-lipoic acid e faʻalauiloaina foʻi le puipuiga o le puipuiga. Na te faia lenei mea e ala i le Nrf-2-faʻutuaina faʻamatalaga o sela o le antioxidant. E fesuiaʻi foʻi genes e manaʻomia se peroxisome faʻalauteleina e faʻagaoioia ai.

O le Alpha-lipoic acid o loʻo taofia ai foʻi le meaola faaniukilia kappa B. Na te faʻagaoioia le AMP-activated protein kinase (AMPK) i auivi o le auivi ma mafua ai le tele o metabolic gaioiga.

E lua ituaiga o alpha-lipoic acid. Latou o oxidized lipoic acid (LA) ma faʻaititia dihydrolipoic acid (DHLA). DHLA e gaosia i le mitochondria o loʻo iai sela i le tino. E mafaia lenei mea ile nikotinamide adenine dinucleotide hydrogen (NADH) ma le lipoamide dehydrogenase. O nei mea e lua fesoasoani i lenei liua tali.

I sela e le lava le mitochondria, e mafai ona faʻaititia le alpha-lipoic acid i le DHLA e ala ile nikotinamide adenine dinucleotide phosphate (NADPH). O lenei gaioiga e fesoasoani i ai le glutathione ma le thioredoxin reductases.

Alpha-lipoic acid o loʻo i ai se meatotino tulaga ese e ese ai mai le glutathione. E ui naʻo le faʻaititia o le glutathione o se vailaʻau e faʻatamaia ai le tino, o vaega uma e faʻaitiitia ma le faʻaititia o le alpha-lipoic acid o ni vailaʻau malolosi.

O le Alpha-lipoic acid o loʻo aʻafia foʻi i le lipeaina o polotini oxidized ma mafai ona fesoasoani i le faʻatulafonoina o le gafa gafa.

O le Alefa-lipoic acid o loʻo iai foi ma vailaʻau faʻaleagaina. E taofia le kappa B kinase, o se enzyme e faʻagaoioi ai le NF-kB, o le itu e fesuiaʻi ai cytokines mumusu [1].

Talaʻaga ole Alpha-lipoic Acid

Na maua le Alpha-lipoic acid i le 1937 e Snell. I lena taimi, sa suʻesuʻeina e saienitisi se ituaiga siama na faʻaaoga ai le vai pateta mo le toe gaosia. 1n 1951, na tuʻua e Reed. O le muamua faʻaoga falemaʻi na amata i Siamani i le 1959 mo le togafitia oona ona o maliu maliu pulou.

O faʻamatalaga e uiga i le faʻaaogaina o le alpha-lipoic acid ma lona aoga e le o maeʻa. O lona faʻaaogaina i togafitiga faʻafomaʻi e leʻi faʻamaonia e le FDA. Ae i le aluga o tausaga, ua maua lauiloa pei o se faʻaopopoga.

O a Itu Itu Aafiaga o le Alpha-lipoic Acid?

Pei o isi vailaʻau, alpha-lipoic acid e iai foʻi ona aʻafiaga.

O nisi o aʻafiaga masani a le alpha-lipoic acid o:

• ulu tīgā
• Heartburn
• faʻafāufau
• Vomiting
• Vaʻavaʻavega
• Lulu o le moli
• Toto toto maualalo
• Paʻu o le paʻu
• Faʻamaʻi

E leʻo iloa aafiaga ole Alpha-lipoic acid paʻu ile maʻitaga ma faʻasusu tina. Ma e fautuaina e aloese mai le faʻaaogaina o lenei pe a maitaga pe faʻasusu.

O a ni penefiti o le Alpha-lipoic Acid?

E tele aoga ole alpha-lipoic acid. O latou na:

Aʻafiaga i Faʻamaʻi Alzheimer

O le alpha-lipoic acid paula e mafai ona faʻatuai le amataga pe faʻatelegese le alualu i luma o le neurodegenerative faamaʻi. O se suʻesuʻega na faia i luga o le toaiva tagata mamaʻi na maua i le Alzheimer faamaʻi. 600mg o Alpha-lipoic acid na tuʻuina i aso uma mo 12 masina [2]. Na mafai ona faʻamautuina le malamalamaʻaga i nei tagata gasegase. Ana meatotino antioxidant ono faʻatelegeseina le tulaga ma ono avea foi o se neuroprotective sooupu.

Aʻafiaga i le maʻisuka

Alepha-lipoic acid mafai ona fesoasoani e tuʻu i lalo le suka suka ile kanesa o le maʻisuka. Talu ai ona o ana vailaʻau faʻamalosi tino e mafai ona aveʻesea Radicals saoloto i le tino, e mafai ona fesoasoani togafitia le faʻaleagaina o sela mafua mai i le maʻisuka. E ono faʻaleleia atili foʻi le teteʻe o le inisalini i tagata maʻisuka. E mafai ona puipuia le oti o beta cells ma ono ono faʻamalosia ai le aveina o le kulukose ma faʻatelegese ai faʻafitauli o le maʻisuka, ae maise lava ole suka ole neuropathy [3].

Aʻafiaga i le Fiva

Alpha-lipoic acid e iai ona tomai faʻapitoa e faʻaaoga ai le neuroprotective. O ana gaioiga faʻamalosi tino e mafai foi ona fesoasoani ile faʻateleina ole neuron ile faiʻai na afaina ile stroke. O se suʻesuʻega na faia i isumu ma ischemic stroke na avatua i ai le alpha-lipoic acid na faʻaalia ai le alualu i luma o latou tulaga [4]. O lea la, e ono fesoasoani e faʻaleleia le tulaga o tagata mamaʻi faʻamaʻi.

Aʻafiaga i le Matua

Ole alpha-lipoic acid pauta e mafai foi ona fesoasoani e faʻatelegese le matua ole paʻu. E mafai e le Alpha-lipoic acid ona tuʻuina atu le tasi eletise i le paʻu e faʻaleagaina ma faʻatamaia ai le soifua maloloina, ma mafua ai ona faʻamamaina ia lava. Lenei auala e mafai ona taofi le matua ma mafai foi faʻatumuina le matafaioi o le le lava vaega o le antioxidant [5]. E mafai foi ona fesoasoani faasaga i le faʻaleagaina na mafua mai i vailaʻau eseese.

Aafiaga i le Mercury Poisoning ma Autism

Alpha-lipoic acid mafai ona pasia le toto-faiʻai papupuni. E mafai foʻi ona faʻaaoga e faʻamamago ai le mercury e faʻapipiʻi i sela o le faiʻai peʻa oʻo i le mercury oona [6]. E mafai ona faʻagaoioia le mole fualaʻau faʻatapulaʻaina i le tafe toto mai le mea e mafai ai e isi chelator agents pei o dimercaptosuccinic acid (DMSA) poʻo le methylsulfonylmethane (MSM) ona faʻalilolilo le mercury i totonu o fatugaʻo ma faʻateʻaina i fafo i le miaga. Talu ai e le mafai e le DMSA poʻo le MSM ona sopoʻia le papala o le toto-faiʻai, faʻaaoga le alpha-lipoic acid ma le DMSA e mafai ona fesoasoani e aveʻese ma le saogalemu le mercury. Lenei mafai foi ona fesoasoani e togafitia autism pei autistic tamaiti maua maualuga tulaga o mercury io latou faiʻai faʻatusatusa i le masani ai. Peitai, suesuega e faatatau i lenei e gata.

Aafiaga i Anemia

O se suʻesuʻega na faia i tagata mamaʻi na i ai i le iuga fatuga faamaʻi ma le anemia lea na tuuina atu ai le alpha-lipoic acid i tagata mamaʻi [7]. Na faʻaalia e agavaʻa pei o le erythropoietin ile faʻateleina ole maualuga ole hemoglobin e aunoa ma se afaina ai. O le mea lea, e mafai ona fesoasoani e togafitia le anemia mafua mai i le faʻaiuga-tulaga toilalo Fatugao. Atonu e aoga tele foi.

Aoga o se Antioxidant

Talu ai o le alpha-lipoic acid pauta o se vailaʻau oʻona, e tele ona aoga ma e mafai ona fesoasoani i le tele o ituaiga o tulaga i le tino.

Aʻafiaga i Neurotoxicity Ona o le ava malosi

Ole 'ava malosi e mafua ai faʻasoesa ole neura ona o le faʻamalosi o le oxidative. Alpha-lipoic acid mafai ona fesoasoani e togafitia neurotoxicity mafua i le 'ava malosi. E mafai ona puipuia le polotini oxidation e tupu i le faʻaaogaina o le ethanol [8].

Aʻafiaga ile Paʻu Paʻu

O le Alpha-lipoic acid e ono avea foʻi ma faʻaopopoga lelei mo le fesoasoani i le leiloa o pauna mo tagata lapoʻa ma tino lapopoʻa [9]. E i ai ona laʻititi aʻafiaga aʻafiaga pe a faʻatusatusa i isi fualaʻau paʻu pauna ma i ai ni vailaʻau puipuia e mafai ona fesoasoani i le tausia o le tagata maloloina.

Contraindications

E le tele ni suʻesuʻega ile faʻafitauli o le alpha-lipoic acid. Ae ui i lea, o nisi tagata mamaʻi ma ni tulaga e tatau ona faʻaeteete ao le i faʻaaogaina lenei vailaʻau ma faʻafesoʻotaʻi ma se fomaʻi ae latou te leʻi faʻaaogaina.

O nisi o nei tuutuuga o:

• Faʻi maʻi
• Faʻateleina le taumafa ava malosi
• Faʻamaʻi thyroid
• Thiamine le lava

Fegalegaleaiga o vailaʻau ma le Alpha-lipoic Acid

E le tele ni faʻamatalaga e uiga i fegalegaleaiga a le alpha-lipoic acid ma isi vailaʻau. Ae o nisi vailaʻau e sili atu ona 'alofia ma lenei faʻaopopoga.

O nisi o nei vailaʻau e:

Fualaʻau o le Hypoglycemic - Alpha-lipoic ua maua suka suka faʻaititia le toto. I nisi tulaga e mafai ona mafua ai inisula autoimmune syndrome, mafua ai hypoglycemia. Ma o le faʻaaogaina ia ma vailaʻau o le hypoglycemic e ono mafua ai le vave hypoglycemia lea e ono mataʻutia.

Vailaau thyroid - Alpha-lipoic acid ono tuʻu i lalo le maualuga o homoneoneone. Ma e manaʻomia le mataʻitu lelei pe a faʻaaogaina ile levothyroxine.

O fea e mafai ona e faʻatau ai Alpha-lipoic Acid i le 2021?

E mafai ona faʻatau saʻo le pauta alapula-lipoic acid mai le kamupani gaosi oloa o le alpha-lipoic acid. E avanoa i se malamalama malamalama samasama i samasama efuefu. E teu i se afifi o le 1 kg i le pepa ma le 25kg i le talipalau. Peitai, o lenei mafai ona suia e tusa ma manaʻoga o le tagata faʻatau.

E manaʻomia le teuina ile vevela 0 ile 4 ° C mo se taimi puʻupuʻu ma -20 ° C mo se taimi umi. E manaʻomia se nofoaga malulu, pogisa, ma mago mo le teuina e puipuia ai mai le tali atu i isi vailaʻau i le siosiomaga. O lenei oloa e faia mai i mea sili ona lelei e mulimuli i faʻatonuga talafeagai.

Faʻasino Upu ua taua

1. Li, G., Fu, J., Zhao, Y., Ji, K., Luan, T., & Zang, B. (2015). O le Alpha-lipoic acid o loʻo faʻaalia ai le anti-inflammatory effects i luga o lipopolysaccharide-stimulated rat mesangial cells e ala i le taofiina o le vaega faaniukilia kappa B (NF-κB) ala faailo. pupuga, 38(2), 510-519.
2. Hager, K., Kenklies, M., McAfoose, J., Engel, J., & Münch, G. (2007). α-lipoic acid o se togafitiga fou mo le faʻamaʻi o le Alzheimer — O le 48 masina o le suʻesuʻega o suʻesuʻega. I totonu Neuropsychiatric Disorder Ose Auala Faʻatasi(itulau 189-193). Springer, Viena
3. Laher, I. (2011). Maʻi suka ma le alpha-lipoic acid. O tuaoi i le fale talavai, 2, 69.
4. Choi, KH, Paka, MS, Kim, HS, Kim, KT, Kim, HS, Kim, JT,… & Cho, KH (2015). Ole togafitiga ole Alpha-lipoic acid ole neurorestorative ma faʻamalosia ai le toe faʻaleleia pe a maeʻa le papala ile isumu. Faiai molecular, 8(1), 1-16.
5. Kim, K., Kim, J., Kim, H., & Sung, GY (2021). Aʻafiaga o le α-Lipoic Acid i le Atinaʻeina o Tagata Paʻu Tutusa Faʻaaogaina o le Pumpless Paʻu-i-a-Chip Faʻataʻitaʻiga. International Journal of Momocular Sciences, 22(4), 2160.
6. Bjørklund, G., Aaseth, J., Crisponi, G., Rahman, MM, & Chirumbolo, S. (2019). Malamalamaaga i luga o alpha-lipoic ma dihydrolipoic acid o ni tagata faʻamanuiaina o le faʻamamaina o le oxidative ma ono mafai ai chelators i le mercury oona. Tusi o talaaga o meaolaolaola, 195, 111-119.
7. El-Nakib, GA, Mostafa, TM, Abbas, TM, El-Shishtawy, MM, Mabrouk, MM, & Sobh, MA (2013). Matafaioi o le alpha-lipoic acid i le puleaina o le anemia i tagata mamaʻi e ogaoga le faʻamaʻi o le fatugao i lalo ole hemodialysis. Tusi faʻavaomalo faʻavaomalo o nephrology ma faʻafouina faʻamaʻi, 6, 161.
8. Pirlich, M., Kiok, K., Sandig, G., Lochs, H., & Grune, T. (2002). O le Alefa-lipoic acid e puipuia le faʻatupuina o le polotini i le ethanol i isumu hippocampal HT22 sela. Neuroscience Letters, 328(2), 93-96.
9. Kucukgoncu, S., Zhou, E., Lucas, KB, & Tek, C. (2017). Alpha ‐ lipoic acid (ALA) o se faʻaopoopoga mo le paʻu o le pauna: iuga mai le faʻataʻitaʻiga o faʻatonutonuina faʻatonutonuina faʻataʻitaʻiga. Mafuaaga Manatu, 18(5), 594-601.

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